Creatine Ethyl Ester Hydrochloride CAS 15366-32-2

1. Creatine ethyl ester hydrochloride CAS 15366-32-2 is a synthetic derivative and prodrug of creatine, developed primarily to improve aqueous solubility and gastrointestinal permeability compared to standard creatine monohydrate for sports nutrition and pharmaceutical research .
2. Creatine ethyl ester hydrochloride has been studied as a potential treatment for neuromuscular disorders and as a radiolabeled tracer compound for pharmacokinetic studies, where carbon, hydrogen, or nitrogen atoms are labeled with 14C, 13C, 2H, 3H, or 15N isotopes .
3. Creatine ethyl ester hydrochloride is utilized in biochemical research to investigate creatine transporter deficiency and as a substrate for creatine kinase studies, where Creatine ethyl ester hydrochloride can be phosphorylated to its corresponding derivative .
4. Researchers employ this compound to evaluate the stability, absorption, and metabolic fate of esterified creatine derivatives, with studies showing pH-dependent conversion to creatinine rather than enzymatic cleavage to creatine in physiological conditions .

1. Creatine ethyl ester hydrochloride CAS 15366-32-2 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment at temperatures not exceeding 25°C, protected from light and moisture to prevent hydrolysis .
2. Creatine ethyl ester hydrochloride is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" according to the harmonized classification .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .
4. Keep Creatine ethyl ester hydrochloride away from incompatible materials such as strong oxidizing agents; store in original container under anhydrous conditions (long-term storage recommended at -15°C) and avoid exposure to elevated pH where rapid degradation occurs (half-life = 23 seconds at pH >8.0) .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves and safety goggles when creatine ethyl ester hydrochloride CAS 15366-32-2 is released.
2. Collect Creatine ethyl ester hydrochloride by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses as discharge into the environment should be avoided.
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. Creatine ethyl ester hydrochloride CAS 15366-32-2 has a melting point of 162-165°C and is not classified as highly flammable, but may decompose under fire conditions emitting toxic fumes .
2. Use Creatine ethyl ester hydrochloride dry chemical powder, carbon dioxide, or water spray appropriate for surrounding materials to extinguish fires involving the product; do NOT use a direct water jet as it may scatter burning material.
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning creatine ethyl ester hydrochloride due to hazardous decomposition gases generated by thermal decomposition.
4. Hazardous decomposition products formed under fire conditions include toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and hydrogen chloride gas; contain fire runoff to prevent environmental contamination and pollution.