1-Boc-3-hydroxypiperidine CAS 85275-45-2

1. 1-Boc-3-hydroxypiperidine CAS 85275-45-2 is a valuable intermediate in pharmaceutical and organic synthesis, consisting of a piperidine ring with a hydroxyl group at the 3-position and a Boc-protected nitrogen, enabling controlled deprotection during multistep synthesis .
2. 1-Boc-3-hydroxypiperidine is widely used in medicinal chemistry to support the development of CNS-active agents, enzyme inhibitors, and other nitrogen-containing therapeutic candidates .
3. The chiral (S)-enantiomer is a crucial synthon for synthesizing pharmaceutical intermediates including ibrutinib, the API of the lymphoma drug Imbruvica, and serves as an important stereoselective intermediate in the synthesis of many anticancer drugs like tyrosine kinase inhibitors .
4. The (R)-enantiomer has been used as a reactant for the synthesis of piperidinyl and pyrrolidinyl butyrates, and for the synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors .

1. 1-Boc-3-hydroxypiperidine CAS 85275-45-2 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light; store in a cool and dark place at ambient temperatures or at -20°C freezer for long-term stability .
2. 1-Boc-3-hydroxypiperidine is incompatible with strong oxidizing agents and heat; it should not be kept or handled near oxidizing agents, and when preparing stock solutions, they should be stored in separate packages to avoid product failure from repeated freeze-thaw cycles .
3. Personnel must wear chemical-resistant gloves and eye/face protection when handling this substance; GHS hazard statements include H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation) .
4. Avoid breathing dust/fume/gas/mist/vapors/spray; if inhaled, remove to fresh air; if in eyes, rinse cautiously with water for several minutes; store locked up and dispose of contents/container in accordance with local/regional/national/international regulations .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 1-Boc-3-hydroxypiperidine CAS 85275-45-2 is released .
2. Collect 1-Boc-3-hydroxypiperidine by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal; avoid creating dust clouds during cleanup .
3. Decontaminate surfaces using appropriate methods; prevent the product from entering drains or water courses as discharge into the environment should be avoided .
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. 1-Boc-3-hydroxypiperidine CAS 85275-45-2 is combustible with a flash point ranging from 104°C (219°F) to 130.6°C, melting point of 46-70°C depending on the enantiomer, and boiling point of 292.3°C at 760 mmHg .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as 1-Boc-3-hydroxypiperidine may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 1-Boc-3-hydroxypiperidine due to hazardous decomposition gases generated by thermal decomposition .
4. Hazardous decomposition products formed under fire conditions include toxic fumes of carbon monoxide, carbon dioxide, and nitrogen oxides (NOx); during combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .