Dihydroberberine CAS 483-15-8

1. Dihydroberberine is a hydrogenated derivative of berberine with improved oral bioavailability, used in research for its anti-hyperuricemic and nephroprotective effects by inhibiting xanthine oxidase (XOD) and modulating urate transporters URAT1 and GLUT9 .
2. Dihydroberberine CAS 483-15-8 exhibits potent anti-inflammatory activity through dual modulation of NF-κB and MAPK signaling pathways, reducing pro-inflammatory mediators including TNF-α, IL-1β, IL-6, and COX-2 expression in inflammatory murine models .
3. Dihydroberberine has demonstrated efficacy in lowering serum uric acid levels, reducing renal damage, and inhibiting NLRP3 inflammasome activation in hyperuricemic mice, with an in vitro XOD inhibitory IC50 value of 34.37 μM .
4. Research applications include studies of anti-atherosclerotic, hypolipidemic, and antitumor activities, as well as investigations of hERG channel inhibition and heat shock protein 90 (Hsp90) modulation .

1. Dihydroberberine powder must be stored in a tightly sealed container at -20°C for long-term stability (up to 3 years) or at 4°C for up to 2 years, protected from light and moisture .
2. For solution storage, prepare aliquots in tightly sealed vials and store at -80°C for up to 6 months or at -20°C for up to 1 month, avoiding repeated freeze-thaw cycles to prevent degradation .
3. Dihydroberberine CAS 483-15-8 contains a pharmaceutically active ingredient and is a moderate to severe irritant to the skin and eyes; personnel must wear chemical-resistant rubber gloves, NIOSH/MSHA-approved respirators, and chemical safety goggles when handling .
4. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases to prevent decomposition; avoid prolonged exposure to light and air as the compound is light-sensitive .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including self-contained breathing apparatus, chemical-resistant rubber gloves, and chemical safety goggles when Dihydroberberine is released .
2. Collect Dihydroberberine CAS 483-15-8 by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol or appropriate methods .
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations; the substance is considered non-hazardous for transport (DOT, IATA, IMDG) .

1. Dihydroberberine is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as Dihydroberberine CAS 483-15-8 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Dihydroberberine due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination and avoid release into waterways .