Corosolic Acid CAS 4547-24-4

1. Corosolic acid CAS 4547-24-4 is a naturally occurring pentacyclic triterpenoid primarily used in research for its antidiabetic properties, where it acts as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 and promotes glucose uptake, making it a popular ingredient in dietary supplements for blood sugar regulation .
2. Corosolic acid exhibits a broad spectrum of therapeutic potential in cancer research, demonstrating the ability to induce apoptosis, inhibit cell proliferation, and modulate key signaling pathways including NF-κB, PI3K/AKT, and Wnt/β-catenin in various cancer cell lines .
3. Corosolic acid is employed in anti-inflammatory and antioxidant studies, where it reduces the expression of pro-inflammatory cytokines such as TNF-α and COX-2, and its cosmeceutical applications are also being explored for cosmetic preparations .
4. Despite its promising bioactivity, Corosolic acid suffers from poor water solubility and low oral bioavailability; therefore, researchers utilize this compound to develop advanced delivery systems such as nanoformulations and chemical derivatives to enhance its solubility, stability, and therapeutic efficacy .

1. Corosolic acid CAS 4547-24-4 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment; powder is stable for up to 3 years at -20°C, 2 years at 4°C, or 2 years at 2-8°C depending on the source .
2. For solution storage, prepare aliquots in tightly sealed vials and store at -80°C for up to 6 months or at -20°C for up to 1 month, avoiding repeated freeze-thaw cycles to prevent degradation .
3. Corosolic acid is not classified as a hazardous substance under GHS criteria according to safety data sheets, though standard laboratory precautions should be observed; Corosolic acid may cause skin, eye, and respiratory tract irritation .
4. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases; the compound is soluble in DMSO (≥10 mg/mL) but has low water solubility .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when Corosolic acid CAS 4547-24-4 is released .
2. For dry spills, collect Corosolic acid by sweeping or vacuuming without creating dust using non-sparking tools; for liquid spills, absorb with finely-powdered liquid-binding materials such as diatomite or universal binders .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol .
4. Prevent the product from entering drains, water courses, or the soil; dispose of collected material according to local, state, and federal environmental regulations .

1. Corosolic acid CAS 4547-24-4 is not classified as highly flammable but may decompose under fire conditions, emitting irritant and potentially toxic fumes .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product .
3. Firefighters Corosolic acid should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Corosolic acid .
4. During combustion, may emit irritant fumes; contain fire runoff to prevent environmental contamination and pollution .