2-Fluoroaniline CAS 348-54-9

1. 2-Fluoroaniline CAS 348-54-9 is widely used as a key intermediate in pharmaceutical synthesis, particularly for developing anti-inflammatory, analgesic, and cardiovascular drugs .
2. 2-Fluoroaniline serves as a crucial building block in agrochemicals for formulating herbicides (e.g., flumetsulam and triazolone esters) and pesticides to enhance crop protection .
3. Applications of 2-Fluoroaniline also include its use in producing dyes with improved stability, developing specialty polymers and resins with enhanced chemical resistance, manufacturing biphenyl-based additives for lithium battery electrolytes, and as a reagent in analytical chemistry .

1. Store 2-Fluoroaniline CAS 348-54-9 in a tightly sealed container under inert gas in a cool, dry, well-ventilated place, protected from light; recommended storage is at 0-8°C (refrigerated) .
2. Keep 2-Fluoroaniline strictly away from strong oxidizing agents, acids, acid anhydrides, acid halides, and chloroformates, as these materials are incompatible and may cause hazardous reactions .
3. Always use 2-Fluoroaniline appropriate personal protective equipment (PPE) including butyl-rubber gloves, tightly fitting safety goggles with faceshield, and chemical-protective clothing; use only with adequate ventilation (fume hood) and avoid breathing vapors, mist, or dust .

1. Immediately isolate the spill area (at least 50 meters/150 feet in all directions), eliminate all ignition sources, and contain 2-Fluoroaniline CAS 348-54-9 using inert, non-combustible absorbent material (dry sand or earth); prevent material from entering drains or waterways .
2. Carefully collect 2-Fluoroaniline using non-sparking tools or an electrically protected vacuum cleaner, and place it into sealed, labeled chemical waste containers for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear full chemical-protective equipment including self-contained breathing apparatus (SCBA) during cleanup; 2-Fluoroaniline is classified for transport and requires hazardous waste disposal .

1. 2-Fluoroaniline CAS 348-54-9 is classified as a flammable liquid (flash point 60°C/140°F) with GHS signal word "Danger," causing severe health hazards including toxicity if swallowed, inhaled, or in contact with skin, serious eye damage (H318), and may cause damage to organs through prolonged or repeated exposure (H373) .
2. 2-Fluoroaniline has a melting point of -29°C, boiling point of 182-183°C, density of 1.151 g/mL, and is slightly soluble in water (17g/l) . Absorption into the body leads to the formation of methemoglobin (cyanosis), with symptoms including bluish tint to fingernails/lips/ears, headache, drowsiness, nausea, and potential unconsciousness . Thermal decomposition produces toxic and corrosive fumes including carbon monoxide, carbon dioxide, nitrogen oxides, and hydrogen fluoride . It is also very toxic to aquatic life with long-lasting effects (H411) .
3. Always consult 2-Fluoroaniline the specific Safety Data Sheet (SDS) for 2-Fluoroaniline for complete hazard information, first-aid procedures, and handling instructions; precautionary statements include P210 (keep away from heat/sparks/open flames), P260 (do not breathe vapors), P273 (avoid release to environment), P280 (wear protective gloves/eye protection), and P403+P233 (store in well-ventilated place, keep container tightly closed) .