O-Toluoyl Chloride CAS 933-88-0

1. O-Toluoyl chloride CAS 933-88-0 is primarily used as an acylating agent and intermediate in organic synthesis, especially in the production of pharmaceuticals, agrochemicals (fungicides and herbicides), and dyes .
2. O-Toluoyl chloride serves as a key building block in material science for modifying polymers and synthesizing functionalized materials, such as novel hydrophobic metal-organic frameworks (UiO-66) with enhanced properties for catalysis and adsorption .
3. Applications of o-Toluoyl chloride also include its use in protecting group chemistry and in the synthesis of fine chemicals and pharmaceutical intermediates .

1. Store o-Toluoyl chloride CAS 933-88-0 in a tightly sealed container under an inert atmosphere in a cool, dry, well-ventilated area away from heat, sparks, and open flames; O-Toluoyl chloride is moisture sensitive and should be stored in a corrosives area .
2. Keep o-Toluoyl chloride strictly away from strong oxidizing agents, strong bases, and alcohols, and protect from contact with water, as O-Toluoyl chloride decomposes to release corrosive and toxic fumes .
3. Always use appropriate personal protective equipment (PPE) including chemical-resistant gloves, tightly fitting safety goggles, and face protection, and handle only in a fume hood to avoid breathing vapors, mist, or gas .

1. Immediately isolate the spill area, eliminate all ignition sources, and provide adequate ventilation; contain o-Toluoyl chloride CAS 933-88-0 using inert, non-combustible absorbent material (e.g., dry sand) and do NOT allow water to contact the spilled material .
2. Carefully collect O-Toluoyl chloride using non-sparking tools into sealed, labeled corrosion-resistant chemical waste containers for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear full chemical-protective equipment including self-contained breathing apparatus (SCBA) during cleanup; prevent material from entering drains or waterways and dispose of all waste as hazardous material.

1. O-Toluoyl chloride CAS 933-88-0 is classified as a corrosive substance (GHS05, Danger) causing severe skin burns and serious eye damage (H314/H318), and may cause respiratory irritation (H335). It is also noted to be a lachrymator (tear gas agent) .
2. O-Toluoyl chloride is combustible with a flash point of 76-77°C (170.6°F) and a boiling point of 88-90°C at 12 mmHg . It reacts with water, and thermal decomposition produces toxic and corrosive fumes including hydrogen chloride, phosgene, and carbon oxides .
3. Always consult O-Toluoyl chloride CAS 933-88-0 the specific Safety Data Sheet (SDS) for o-Toluoyl chloride for complete hazard information, first-aid procedures, and handling instructions; precautionary statements include P260 (do not breathe vapors), P280 (wear protective gloves/eye protection), and P310 (immediately call a poison center/doctor) .