2-Fluorobenzyl Bromide CAS 446-48-0

1. 2-Fluorobenzyl bromide is a key intermediate in pharmaceutical synthesis, particularly for developing drugs targeting neurological disorders like Alzheimer's and Parkinson's (e.g., the neuroprotective agent Fluorolintane) and for synthesizing anticonvulsants .
2. 2-Fluorobenzyl bromide CAS 446-48-0 is widely used as an alkylating agent in organic synthesis for preparing fluorinated compounds and building complex molecules such as 2-pyrrolo[2,3-d]pyrimidines, 8-alkylated imidazolo[1,2-a]pyrimid-5-ones, and the antiplatelet drug prasugrel .
3. Applications of 2-Fluorobenzyl bromide also include agrochemical development for more effective pesticides/herbicides, material science for specialty polymers, and fluorine chemistry research .

1. Store 2-Fluorobenzyl bromide in a tightly sealed container under inert gas (argon) in a cool, dry, well-ventilated area away from heat, sparks, and open flames; recommended temperatures range from 0-8°C (refrigerated) to room temperature in a cool (<15°C), dark place .
2. Keep 2-Fluorobenzyl bromide strictly away from strong oxidizing agents, bases, amines, alcohols, and moisture, as it is hygroscopic and reacts with water to form toxic and corrosive fumes .
3. Always use 2-Fluorobenzyl bromide CAS 446-48-0 appropriate personal protective equipment (PPE) including chemical-resistant gloves, tightly fitting safety goggles, face protection, and protective clothing; use only in a fume hood with explosion-proof equipment and avoid breathing vapors, mist, or dust .

1. Immediately isolate the spill area, eliminate all ignition sources, and ensure adequate ventilation; contain 2-Fluorobenzyl bromide using inert, non-combustible absorbent material (e.g., dry sand) and absolutely avoid contact with water .
2. Carefully collect 2-Fluorobenzyl bromide CAS 446-48-0 using non-sparking tools or an explosion-proof vacuum cleaner, and place it into a sealed, corrosion-resistant chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear full chemical-protective equipment including self-contained breathing apparatus (SCBA) during cleanup; prevent material from entering drains or waterways and dispose of all waste as hazardous material (UN3265, Hazard Class 8, PG II) .

1. 2-Fluorobenzyl bromide is classified as a corrosive (GHS05, Danger) causing severe skin burns and serious eye damage (H314/H318), and is a combustible liquid (H227) with a flash point of 82-83°C .
2. 2-Fluorobenzyl bromide may cause respiratory irritation (H335) and is a lachrymator (tear gas agent); thermal decomposition or combustion produces toxic and corrosive fumes including carbon oxides, hydrogen fluoride, and hydrogen bromide .
3. Always consult 2-Fluorobenzyl bromide CAS 446-48-0 the specific Safety Data Sheet (SDS) for 2-Fluorobenzyl bromide for complete hazard information, first-aid procedures (P301+P330+P331 for ingestion, P303+P361+P353 for skin, P305+P351+P338 for eyes, P304+P340 for inhalation), and handling instructions .