2-Fluorobenzoyl Chloride CAS 393-52-2

1. 2-Fluorobenzoyl chloride is widely utilized as a key pharmaceutical intermediate in synthesizing anti-inflammatory, analgesic, and antiviral drugs .
2. 2-Fluorobenzoyl chloride CAS 393-52-2 serves as a crucial building block in organic synthesis for introducing the 2-fluorobenzoyl group into complex molecules, enabling the development of new materials with tailored properties .
3. 2-Fluorobenzoyl chloride is employed in polymer chemistry to improve thermal stability and chemical resistance of specialty polymers, and in analytical chemistry for preparing derivatizing agents to enhance detection sensitivity .

1. Store 2-Fluorobenzoyl chloride under inert gas (argon or nitrogen) in a tightly sealed container in a cool, dry, well-ventilated place at 2-8°C, as 2-Fluorobenzoyl chloride is moisture sensitive and decomposes in water .
2. Keep 2-Fluorobenzoyl chloride CAS 393-52-2 strictly away from strong oxidizing agents, bases, alcohols, and amines, as 2-Fluorobenzoyl chloride is incompatible with these materials and may react violently .
3. Handle 2-Fluorobenzoyl chloride using appropriate personal protective equipment including chemical-resistant gloves, tightly fitting safety goggles with face shield, and in a fume hood to avoid breathing vapors and contact with skin and eyes .

1. Isolate the spill area (at least 50 meters/150 feet), eliminate all ignition sources, and contain liquid 2-Fluorobenzoyl chloride using dry inert absorbent material like sand, preventing entry into drains or waterways .
2. Collect absorbed 2-Fluorobenzoyl chloride CAS 393-52-2 using non-sparking, explosion-proof tools into sealed, labeled corrosion-resistant containers for disposal according to hazardous material regulations .
3. Personnel cleaning 2-Fluorobenzoyl chloride spills must wear full protective equipment including self-contained breathing apparatus, as 2-Fluorobenzoyl chloride is corrosive and a lachrymator, and discharge into the environment must be strictly avoided .

1. 2-Fluorobenzoyl chloride is classified as a corrosive liquid (GHS05, Danger) causing severe skin burns and serious eye damage (H314, H318), with GHS signal word "Danger" and NFPA health rating of 3 (serious hazard) .
2. 2-Fluorobenzoyl chloride is a combustible liquid (H227, flash point 82°C/180°F) and may be corrosive to metals (H290); when heated to decomposition, 2-Fluorobenzoyl chloride CAS 393-52-2 emits toxic fumes including hydrogen chloride and hydrogen fluoride .
3. 2-Fluorobenzoyl chloride is harmful if swallowed (oral LD50 >2000 mg/kg), causes respiratory irritation (H335), and is classified for transport as a corrosive liquid (UN 3265, Hazard Class 8, Packing Group II/III) requiring storage locked up with container tightly closed (P403+P233, P405) .