2-Fluoroacetophenone CAS 445-27-2

1. 2-Fluoroacetophenone serves as a crucial starting material for synthesizing the antiasthmatic drug Montelukast and the potassium-competitive acid blocker vonoprazan fumarate .
2. 2-Fluoroacetophenone CAS 445-27-2 enables one-pot synthesis of chromone-2-carboxylate scaffolds, a pharmacophore with diverse biological properties, allowing access to natural products like halenic acids .
3. 2-Fluoroacetophenone acts as a substrate for engineered tryptophan synthase (TrpB) in asymmetric alkylation reactions to produce non-canonical amino acids and nitrogen heterocycles .

1. Store 2-Fluoroacetophenone in a tightly sealed container in a cool, dark place below 15°C, away from heat, sparks, and open flames .
2. Keep 2-Fluoroacetophenone CAS 445-27-2 strictly away from strong oxidizing agents and strong bases, as it is incompatible with these materials .
3. Handle 2-Fluoroacetophenone using appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and in a fume hood to avoid breathing vapors and contact with skin and eyes .

1. Isolate the spill area, eliminate all ignition sources, and contain liquid 2-Fluoroacetophenone using dry inert absorbent material like sand, preventing entry into drains or waterways .
2. Collect absorbed 2-Fluoroacetophenone CAS 445-27-2 using non-sparking, explosion-proof tools into sealed, labeled containers for disposal according to environmental regulations .
3. Personnel cleaning 2-Fluoroacetophenone spills must wear full protective equipment including self-contained breathing apparatus, as vapors may accumulate and the compound is a combustible liquid (UN 1993) .

1. 2-Fluoroacetophenone is harmful if swallowed, in contact with skin, or if inhaled (H302+H312+H332), and causes skin and serious eye irritation (H315, H319) with GHS signal word "Warning" .
2. 2-Fluoroacetophenone CAS 445-27-2 is a combustible liquid (flash point 61-62°C) with an NFPA health rating of 2, and combustion produces toxic fumes including carbon monoxide and hydrogen fluoride .
3. 2-Fluoroacetophenone has a melting point of 26-27°C, density of 1.137 g/mL, and is classified for transport as a flammable liquid (UN1993, Hazard Class 3, PG III) with CAS number 445-27-2 .