M-(Trifluoromethyl)phenylacetic Acid CAS 351-35-9

1. m-(Trifluoromethyl)phenylacetic acid CAS 351-35-9 is a valuable intermediate in the synthesis of various drug compounds, as the trifluoromethyl group can enhance the biological activity and metabolic stability of pharmaceutical candidates .
2. m-(Trifluoromethyl)phenylacetic acid serves as a cornerstone in organic synthesis for developing fluorinated compounds of great interest in medicinal chemistry and agrochemicals .
3. m-(Trifluoromethyl)phenylacetic acid is also used in the synthesis of agrochemicals, including herbicides and pesticides, where fluorine compounds are often used to enhance their performance .

1. Store m-(Trifluoromethyl)phenylacetic acid CAS 351-35-9 in a tightly sealed container in a cool, dry, well-ventilated place at controlled room temperature (ideally 15-25°C), away from direct sunlight, heat sources, and incompatible materials .
2. Keep m-(Trifluoromethyl)phenylacetic acid in a dedicated chemical storage cabinet, use airtight containers made of compatible materials like glass or high-density polyethylene, and ensure containers remain tightly closed when not in use to prevent moisture absorption and contamination .
3. Handle m-(Trifluoromethyl)phenylacetic acid using appropriate personal protective equipment including gloves and goggles, and regularly inspect storage areas for signs of leaks, damage, or degradation .

1. Isolate the spill area and use personal protective equipment; avoid generating dust, ensure adequate ventilation, and use spark-proof tools for large spills .
2. Sweep up spilled m-(Trifluoromethyl)phenylacetic acid into sealed, labeled containers for disposal without creating dust; for small amounts, dampen with acetone before transfer if needed .
3. Personnel cleaning m-(Trifluoromethyl)phenylacetic acid spills must wear suitable protective equipment, prevent entry into drains or waterways, and dispose of waste according to environmental regulations .

1. m-(Trifluoromethyl)phenylacetic acid CAS 351-35-9 causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335), with GHS signal word "Warning" .
2. m-(Trifluoromethyl)phenylacetic acid has a flash point of 106.1°C; combustion or thermal decomposition produces toxic fumes including carbon oxides and hydrogen fluoride .
3. m-(Trifluoromethyl)phenylacetic acid is classified with hazard codes Xi (Irritant) and risk phrases R36/37/38, with safety instructions including S26, S36, and S37/39 .