2-Nitroacetophenone CAS 577-59-3

1. 2-Nitroacetophenone is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals, and dyestuff . It serves as a versatile synthetic reagent and sensitizer for pharmaceutical intermediates .
2. 2-Nitroacetophenone CAS 577-59-3 is utilized in the production of 2-nitro-benzoic acid at 20°C and participates in reactions such as the asymmetric transfer hydrogenation of functionalized aromatic ketones to synthesize optically active amino alcohols .
3. Applications of 2-Nitroacetophenone also include its use in reduction reactions with lithium aluminum hydride and as a building block in patent literature for modulators of stimulator of interferon genes (STING) and other bioactive molecules .

1. Store 2-Nitroacetophenone in a tightly sealed container in a cool, dry, and well-ventilated place, away from direct sunlight and heat sources . Recommended storage is at ambient temperatures or in a cool, dry area .
2. Keep 2-Nitroacetophenone CAS 577-59-3 strictly away from strong oxidizing agents and strong bases, as it is incompatible with these materials .
3. Always use appropriate personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, and protective clothing when handling 2-Nitroacetophenone to avoid contact with skin, eyes, and inhalation of dust or vapors .

1. Immediately isolate the spill area and ensure adequate ventilation. Contain 2-Nitroacetophenone using dry, inert, non-combustible absorbent material (e.g., sand) and prevent entry into drains or waterways .
2. Carefully sweep up the spilled 2-Nitroacetophenone using clean, non-sparking tools and place the collected material into sealed, labeled chemical waste containers for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must 2-Nitroacetophenone CAS 577-59-3 wear suitable PPE, including self-contained breathing apparatus (SCBA) if necessary, during cleanup. 2-Nitroacetophenone is classified for transport (UN number may vary; Hazard Class 6.1 or not hazardous by some determinations) .

1. 2-Nitroacetophenone is classified with a GHS signal word "Warning" and is harmful if swallowed (H302), with acute oral toxicity (LD50 rat: 665 mg/kg) . 2-Nitroacetophenone CAS 577-59-3 is a combustible liquid with a flash point ranging from >110°C (230°F) to 112°C .
2. 2-Nitroacetophenone may cause skin, eye, and respiratory tract irritation upon contact or inhalation, and thermal decomposition produces toxic and irritating fumes including nitrogen oxides and carbon oxides . 2-Nitroacetophenone CAS 577-59-3 is insoluble in water .
3. Always consult the specific Safety Data Sheet (SDS) for 2-Nitroacetophenone for complete hazard information, first-aid procedures (P301+P312+P330 for ingestion, P305+P351+P338 for eyes), and handling instructions; precautionary statements include P264 (wash thoroughly after handling), P270 (do not eat/drink when using), and P280 (wear protective gloves/eye protection) .