3'-Chloropropiophenone CAS 34841-35-5

1. 3'-Chloropropiophenone is primarily used as a key intermediate in the synthesis of pharmaceuticals, notably the antidepressant bupropion (hydrochloride) and other drugs such as dapoxetine and maraviroc . It also serves as an impurity standard for fluoxetine .
2. 3'-Chloropropiophenone CAS 34841-35-5 acts as a versatile building block in organic synthesis, undergoing reactions like reduction, nucleophilic substitution, and oxidation to create various fine chemicals, agrochemicals (herbicides, pesticides), and heterocyclic derivatives .
3. Applications of 3'-Chloropropiophenone also include its use in research to explore new reaction pathways and synthesize complex organic molecules, as well as a precursor for specialty chemicals and fragrances .

1. Store 3'-Chloropropiophenone in a tightly sealed container in a cool, dry, and well-ventilated area, away from heat, light, and incompatible substances like strong oxidizing agents and bases . Recommended storage temperatures include ambient conditions, a cool, dark place, or at -20°C for long-term stability .
2. Keep 3'-Chloropropiophenone in an inert atmosphere if possible, and protect from light, as it is light-sensitive . Stability is maintained under standard ambient conditions when stored properly .
3. Always use 3'-Chloropropiophenone CAS 34841-35-5 appropriate personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, and protective clothing; avoid breathing dust and ensure adequate ventilation when handling 3'-Chloropropiophenone to prevent irritation .

1. Immediately isolate the spill area, contain 3'-Chloropropiophenone using inert, non-combustible absorbent material (e.g., sand), and prevent dust generation; avoid entry into drains or waterways .
2. Carefully sweep 3'-Chloropropiophenone CAS 34841-35-5 up the spilled 3'-Chloropropiophenone solid using clean, non-sparking tools and place the collected material into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear suitable PPE including self-contained breathing apparatus (SCBA) if necessary during cleanup; under fire conditions, toxic fumes including carbon oxides and hydrogen chloride may be released, requiring full protective gear . The compound is not classified as dangerous goods for transport by some regulations .

1. 3'-Chloropropiophenone is classified as an irritant (GHS signal word "Warning") causing skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335) . It is harmful if swallowed, inhaled, or absorbed through the skin .
2. 3'-Chloropropiophenone is combustible with a flash point >110-113°C (>230°F) . It is stable under normal conditions but incompatible with strong oxidizing agents and strong bases; thermal decomposition produces toxic and irritating fumes including carbon monoxide, carbon dioxide, and hydrogen chloride .
3. Always consult 3'-Chloropropiophenone CAS 34841-35-5 the specific Safety Data Sheet (SDS) for 3'-Chloropropiophenone for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P302+P352 for skin, P301+P330+P331 for ingestion), and handling instructions; precautionary statements include P261 (avoid breathing dust), P271 (use only outdoors or in well-ventilated area), and P280 (wear protective gloves/eye protection) .