4-Acetamidobenzenesulfonyl Azide /p-ABSA CAS 2158-14-7

4-Acetamidobenzenesulfonyl azide/p-ABSA (CAS:2158-14-7) is an important pharmaceutical intermediates.

Its main applications including:

1. 4-Acetamidobenzenesulfonyl azide is specialized sulfonyl azide reagent for diazotization in pharmaceutical intermediate synthesis.
2. p-ABSA is used to prepare diazo compounds for cyclization, insertion and click heterocyclization reactions.
3. 4-Acetamidobenzenesulfonyl azide serves as functional reagent in fine chemical research for nitrogen-containing molecular construction.

1. Keep tightly sealed and store below 20°C in dry dark storage to avoid light-induced decomposition of azide moiety.
2. Strictly avoid mechanical friction, impact and high temperature heating to prevent explosive decomposition.
3. Store separately from heavy metal salts, concentrated mineral acids and strong reducing agents.

1. Avoid inhalation of crystalline dust; wear explosion-proof goggles, dust mask and chemical resistant gloves.
2. Do not swallow the solid; flush contaminated eyes and skin with plenty of cold running water immediately after contact.
3. Dispose residual solids and waste filtrate in full compliance with hazardous azide chemical waste disposal standards.

1. Moderate diazo transfer activity suitable for selective conversion of active methylene substrates.
2. Acetamide group improves stability and reduces spontaneous decomposition risk compared with unsubstituted tosyl azide.
3. Good solubility in anhydrous polar organic solvents for convenient laboratory synthetic operations.