4-Chlorobenzyl Cyanide CAS 140-53-4

1. 4-Chlorobenzyl cyanide CAS 140-53-4 is a crucial intermediate in the multi-kilogram synthesis of the muscle relaxant drug baclofen via C–C bond formation .
2. 4-Chlorobenzyl cyanide serves as a key building block for the insecticidal pyrethroid etofenprox and is used to prepare the antimalarial drug pyrimethamine .
3. 4-Chlorobenzyl cyanide is also employed as a precursor in synthesizing various agrochemicals and dyes .

1. Store 4-Chlorobenzyl cyanide CAS 140-53-4 in a tightly sealed container in a cool, dry, well-ventilated area, away from oxidizing agents and temperatures exceeding 30°C .
2. Keep 4-Chlorobenzyl cyanide containers locked up and protected from physical damage, as contact with metals may evolve flammable hydrogen gas .
3. Handle 4-Chlorobenzyl cyanide using appropriate personal protective equipment including chemical-resistant gloves (fluorinated rubber), face shield, and in a fume hood to avoid breathing dust or vapors .

1. Isolate the spill 4-Chlorobenzyl cyanide CAS 140-53-4 area, wear full protective equipment including self-contained breathing apparatus, and avoid creating dust when handling solid 4-Chlorobenzyl cyanide .
2. Sweep up spilled 4-Chlorobenzyl cyanide into sealed, labeled containers for disposal according to environmental regulations .
3. Prevent spilled 4-Chlorobenzyl cyanide from entering drains or waterways, as the compound is highly toxic to aquatic life .

1. 4-Chlorobenzyl cyanide CAS 140-53-4 is fatal if swallowed (LD50 oral rat: 50 mg/kg), toxic in contact with skin, and toxic if inhaled with GHS signal word "Danger" .
2. 4-Chlorobenzyl cyanide causes severe skin burns, serious eye damage (H314/H318), and may cause respiratory irritation (H335) .
3. Combustion of 4-Chlorobenzyl cyanide produces toxic fumes including hydrogen chloride gas, hydrogen cyanide, and nitrogen oxides; NFPA health rating is 3 (serious hazard) .