Chloranil CAS 118-75-2

1. Chloranil is widely used as a mild oxidant and hydrogen acceptor in organic synthesis for aromatization reactions, such as the conversion of cyclohexadienes to benzene derivatives . It is also employed as a key reagent in the production of pharmaceuticals, including the cancer chemotherapeutic agent diaziquone (AZQ) and in the synthesis of the anti-cancer drug exemestane .
2. Chloranil CAS 118-75-2 serves as an important intermediate for the synthesis of dyes, notably pigment violet 23 . It is also utilized in analytical chemistry as a chromogenic reagent for the spectrophotometric determination of various tranquilizers and antidepressants and as a test for free secondary amines (e.g., proline derivatives), producing a characteristic color change .
3. Applications of Chloranil also include its historical use as a fungicide for seed and bulb treatment in agriculture , and as a building block in materials science for preparing fluorescent carbon dots for bioimaging applications .

1. Store Chloranil in a tightly sealed container in a cool, dry, and well-ventilated place, protected from light and heat as it is sensitive to both . Recommended storage conditions vary: for powder form, store at -20°C (long-term, 3 years) or 4°C (2 years); for solutions, store at -80°C (6 months) or -20°C (1 month) .
2. Keep Chloranil away from strong oxidizing agents and alkalis, as it is incompatible with these materials . The substance is non-combustible but may decompose on heating, producing toxic fumes including hydrogen chloride .
3. Always Chloranil CAS 118-75-2 use appropriate personal protective equipment (PPE) including chemical-resistant gloves, tightly fitting safety goggles, and NIOSH-approved respiratory protection (organic vapor/acid gas cartridge with dust/mist filter) when handling Chloranil to avoid dust inhalation and contact with skin and eyes . Handle only in a well-ventilated area or fume hood.

1. Immediately isolate the spill area, use full personal protective equipment (including self-contained breathing apparatus), and avoid generating dust . Do NOT wash away into sewer and prevent entry into drains or waterways, as Chloranil is very toxic to aquatic life with long-lasting effects (H410) .
2. For small spills, dampen the solid Chloranil material with acetone, then carefully sweep up or collect the dampened material using non-sparking tools and place Chloranil CAS 118-75-2 into a sealed, labeled chemical waste container for proper disposal . Use absorbent paper dampened with acetone to pick up any remaining material, and wash all contaminated surfaces with acetone followed by soap and water .
3. Personnel must wear suitable PPE, including chemical-resistant gloves and protective clothing, during cleanup . Dispose of all waste according to local, state, and federal environmental regulations. Chloranil is classified for transport as UN3077 (Hazard Class 9, Packing Group III) by some sources .

1. Chloranil is classified with GHS signal word "Warning" . It causes skin irritation (H315), serious eye irritation (H319), and is very toxic to aquatic life with long-lasting effects (H410) . Acute toxicity data includes oral LD50 of 4 gm/kg in rats and LC50 (inhalation) of 2485 mg/m³/4h in rats .
2. Chloranil CAS 118-75-2 is a yellow solid (powder or various forms) with a melting point of 290-296°C (decomposes), is insoluble in water , and has a vapor density of 8.5 (air=1), indicating vapors are heavier than air . The substance is sensitive to excessive light and heat . It decomposes on heating, producing toxic fumes including hydrogen chloride, carbon monoxide, and chlorine .
3. Chloranil may be harmful by eye or skin contact, inhalation or ingestion . Symptoms of exposure include irritation of the skin, eyes, and respiratory tract, as well as possible central nervous system effects . Always consult the specific Safety Data Sheet (SDS) for Chloranil for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P302+P352 for skin), and handling instructions. Precautionary statements include P273 (avoid release to environment), P280 (wear protective gloves/eye protection), and P391 (collect spillage) .