Sodium Tert-butoxide CAS 865-48-5

1. Sodium tert-butoxide is a strong, non-nucleophilic base widely used in organic synthesis for condensation, rearrangement, and ring-opening reactions . Sodium tert-butoxide CAS 865-48-5 serves as an intermediate in the production of pharmaceuticals, agrochemicals, colorants, aroma chemicals, and detergents .
2. The compound is utilized in palladium-catalyzed amination reactions (Buchwald-Hartwig) for synthesizing aryl amines and aryl tert-butyl ethers, and acts as a catalyst in transesterification reactions for biodiesel production .
3. Applications of Sodium tert-butoxide also include its use in the synthesis of adefovir intermediates, as a base for preparing sodium acrylate from olefins and CO₂, and as a component in sodium diisobutyl-t-butoxyaluminum hydride (SDBBA) for reducing esters to aldehydes .

1. Store Sodium tert-butoxide in a tightly sealed container under inert gas (e.g., argon) in a cool, dry, and well-ventilated place, protected from moisture and sunlight . Recommended storage is below 15°C in a dark, cool area .
2. Keep Sodium tert-butoxide strictly away from water, moisture, acids, alcohols, chlorinated solvents, and oxidizing agents, as it reacts violently with water, releases flammable gases (hydrogen), and is self-heating, which may cause fire . Maintain an air gap between pallets and store away from other materials .
3. Always Sodium tert-butoxide CAS 865-48-5 use appropriate personal protective equipment (PPE) including tightly fitting safety goggles or face shield, flame-retardant antistatic protective clothing, and chemical-resistant gloves (nitrile rubber, minimum 0.11 mm thickness). Use only in well-ventilated areas or fume hoods with explosion-proof equipment, and avoid breathing dust .

1. Immediately isolate the spill area, evacuate non-essential personnel, eliminate all ignition sources, and ensure adequate ventilation. DO NOT use water; absolutely prevent contact with moisture .
2. Contain Sodium tert-butoxide using dry, inert, non-combustible absorbent material (dry sand or earth). Carefully sweep up or vacuum with spark-proof tools, avoiding dust generation, and place collected material into sealed, labeled corrosion-resistant chemical waste containers for proper disposal according to hazardous material regulations .
3. Personnel Sodium tert-butoxide CAS 865-48-5 must wear full chemical-protective equipment including self-contained breathing apparatus (SCBA) during cleanup. Prevent entry into drains or waterways. Sodium tert-butoxide is classified for transport (UN3206 or UN2925, Hazard Class 4.2/8, Packing Group II) .

1. Sodium tert-butoxide is classified with GHS signal word "Danger". It causes severe skin burns and serious eye damage (H314/H318), is a flammable solid (H228) and self-heating (H251), may cause respiratory irritation (H335), and is suspected of causing cancer (H351) .
2. Sodium tert-butoxide reacts violently with water, releasing flammable gases (hydrogen) that may ignite spontaneously. Its flash point is 12-14°C . Thermal decomposition produces toxic and irritating fumes including carbon monoxide, carbon dioxide, and sodium oxides . NFPA health rating is 3 (serious hazard), fire rating 3, reactivity 2 .
3. Always Sodium tert-butoxide CAS 865-48-5 consult the specific Safety Data Sheet (SDS) for Sodium tert-butoxide for complete hazard information, first-aid procedures (P303+P361+P353 for skin, P305+P351+P338+P310 for eyes, P304+P340+P310 for inhalation, P301+P330+P331 for ingestion - do NOT induce vomiting), and handling instructions. Precautionary statements include P210 (keep away from heat/sparks/open flames), P235+P410 (keep cool, protect from sunlight), P260 (do not breathe dust), and P280 (wear protective gloves/eye protection) .