Cyclopropyl Bromide CAS 4333-56-6

1. Cyclopropyl bromide is primarily used as a key intermediate in the manufacture of pharmaceutical and agrochemical products, particularly in the synthesis of fluoronaphthyridone antibacterial agents and fluoroquinolone antibiotics such as cyclopropane carboxylic acid derivatives .
2. Cyclopropyl bromide CAS 4333-56-6 serves as a versatile building block in organic synthesis for producing cyclopropyl boric acid and participates in ring-opening reactions, nucleophilic substitutions, and metal-catalyzed transformations due to its strained ring structure and reactive bromine substituent .
3. Applications of Cyclopropyl bromide also include its use in the development of pharmaceuticals with anti-angiogenic effects that inhibit new blood vessel growth by interfering with prostaglandin and nitric oxide production .

1. Store Cyclopropyl bromide in a tightly sealed container in a cool, dry, and well-ventilated place; recommended storage temperatures are 2-8°C (refrigerated) or at -20°C for long-term stability of powders .
2. Keep Cyclopropyl bromide strictly away from heat, sparks, open flames, strong oxidizing agents, and strong bases due to its high flammability and incompatibility with these materials .
3. Always use Cyclopropyl bromide CAS 4333-56-6 appropriate personal protective equipment (PPE) including chemical-resistant gloves, tightly fitting safety goggles, face shield, and protective clothing; handle only with explosion-proof equipment and adequate ventilation in a fume hood, and take measures to prevent static discharge .

1. Immediately isolate the spill area, eliminate all ignition sources, and ensure adequate ventilation; contain Cyclopropyl bromide using inert, non-combustible absorbent material (e.g., dry sand) and prevent entry into drains or waterways .
2. Carefully collect Cyclopropyl bromide CAS 4333-56-6 using an electrically protected vacuum cleaner, by wet-brushing, or with non-sparking tools, and place it into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear full chemical-protective clothing including self-contained breathing apparatus (SCBA) during cleanup; Cyclopropyl bromide is classified for transport (UN1993, Hazard Class 3, PG II) as a flammable liquid and requires hazardous waste disposal .

1. Cyclopropyl bromide is classified as a highly flammable liquid and vapor (H225, Danger) with a flash point ranging from -7°C to 20°F (-6°C) . It is a skin and strong eye irritant (H315+H319) and may cause respiratory irritation (H335) .
2. Cyclopropyl bromide has a boiling point of 68-70°C and density of 1.51 g/mL . Its thermal decomposition or combustion produces toxic and irritating fumes including carbon oxides and hydrogen bromide gas . The substance is a lachrymator (tear gas agent) .
3. Always consult Cyclopropyl bromide CAS 4333-56-6 the specific Safety Data Sheet (SDS) for Cyclopropyl bromide for complete hazard information, first-aid procedures (P303+P361+P353 for skin, P305+P351+P338 for eyes, P301+P330+P331 for ingestion, P304+P340 for inhalation), and handling instructions. Precautionary statements include P210 (keep away from heat/sparks/open flames), P233 (keep container tightly closed), P240 (ground/bond container), P261 (avoid breathing vapors), and P280 (wear protective gloves/eye protection) .