3-Fluorobenzyl Bromide CAS 456-41-7

1. 3-Fluorobenzyl bromide CAS 456-41-7 is primarily used as a key intermediate in the synthesis of pharmaceuticals, including antidiabetic, antiviral, and anticancer agents, leveraging the fluorine atom to enhance drug efficacy and metabolic stability .
2. 3-Fluorobenzyl bromide serves as a versatile building block in organic synthesis for introducing the 3-fluorobenzyl group into target molecules, such as in the preparation of protecting groups for alcohols and for bioconjugation in drug delivery systems .
3. Applications of 3-Fluorobenzyl bromide also include its use in material science for developing specialty polymers, in phase transfer catalysis, and as a reagent in the synthesis of biologically active compounds like sydnones .

1. Store 3-Fluorobenzyl bromide CAS 456-41-7 in a tightly sealed container under an inert atmosphere in a cool, dry, and well-ventilated place, protected from light; recommended storage temperatures are 2-8°C (refrigerated) or 0-8°C .
2. Keep 3-Fluorobenzyl bromide away from strong oxidizing agents and moisture, as it is moisture sensitive and incompatible with these materials .
3. Always use 3-Fluorobenzyl bromide appropriate personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, face shield, and protective clothing; handle only with adequate ventilation and avoid breathing dust, vapors, or mist .

1. Immediately isolate the spill area, eliminate all ignition sources, and ensure adequate ventilation; contain 3-Fluorobenzyl bromide CAS 456-41-7 using inert, non-combustible absorbent material (e.g., dry sand) and prevent entry into drains or waterways .
2. Carefully collect 3-Fluorobenzyl bromide using non-sparking or spark-proof tools, or use an explosion-proof vacuum, and place it into a sealed, labeled corrosive-resistant chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear suitable PPE including chemical-protective clothing and self-contained breathing apparatus (SCBA) during cleanup; 3-Fluorobenzyl bromide is classified for transport (UN3265, Hazard Class 8, PG II) and requires hazardous waste disposal .

1. 3-Fluorobenzyl bromide CAS 456-41-7 is classified as a corrosive substance (GHS05, Danger) causing severe skin burns and serious eye damage (H314/H318). It is a known lachrymator (tear gas agent) and may cause respiratory irritation (H335) .
2. 3-Fluorobenzyl bromide is a combustible liquid (H227) with a flash point of 61-62°C . It may be corrosive to metals (H290) and reacts with water to form toxic fumes; thermal decomposition produces toxic and irritating fumes including carbon monoxide and hydrogen fluoride .
3. Always consult 3-Fluorobenzyl bromide CAS 456-41-7 the specific Safety Data Sheet (SDS) for 3-Fluorobenzyl bromide for complete hazard information, first-aid procedures, and handling instructions; precautionary statements include P210 (keep away from heat/sparks/open flames), P260 (do not breathe vapors), P280 (wear protective gloves/eye protection), and P310 (immediately call a poison center/doctor) .