3-Chlorophenylacetic Acid CAS 1878-65-5

1. 3-Chlorophenylacetic acid CAS 1878-65-5 is primarily used as a versatile building block in organic synthesis for the preparation of various pharmaceuticals and agrochemicals . 3-Chlorophenylacetic acid serves as a key intermediate in the development of drugs for treating inflammation and bacterial infections .
2. 3-Chlorophenylacetic acid is also employed as a precursor in the synthesis of biologically active molecules, such as enzyme inhibitors and receptor agonists . It can be used to synthesize other derivatives like (3-Chlorophenyl)acetyl chloride .
3. Applications of 3-Chlorophenylacetic acid include its role as a chemical intermediate for producing other fine chemicals and research compounds .

1. Store 3-Chlorophenylacetic acid CAS 1878-65-5 in a tightly sealed container in a cool, dry, and well-ventilated area . Recommended storage temperatures are at 2-8°C (refrigerated) or in a cool, dry place .
2. Keep 3-Chlorophenylacetic acid away from strong oxidizing agents to prevent hazardous reactions, as this is a known incompatibility .
3. Always use 3-Chlorophenylacetic acid appropriate personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, and protective clothing when handling 3-Chlorophenylacetic acid to avoid skin, eye, and respiratory contact .

1. Immediately isolate the spill area, avoid dust formation, and contain 3-Chlorophenylacetic acid CAS 1878-65-5 using inert, non-combustible absorbent material; prevent material from entering drains or waterways .
2. Carefully sweep 3-Chlorophenylacetic acid up the spilled solid using clean, non-sparking tools and place the collected material into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear suitable PPE during cleanup; under fire conditions, wear self-contained breathing apparatus (SCBA) as thermal decomposition produces toxic and irritating fumes including hydrogen chloride, carbon monoxide, and carbon dioxide .

1. 3-Chlorophenylacetic acid CAS 1878-65-5 is classified as an irritant (GHS signal word "Warning"), causing skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335) . The EC Risk Phrase is R 36/37/38 (irritating to eyes, respiratory system, and skin) .
2. 3-Chlorophenylacetic acid has a melting point of 76-79°C and a pKa of approximately 4.12 . It is incompatible with strong oxidizing agents, and its decomposition produces toxic fumes including hydrogen chloride gas . The toxicological properties have not been fully investigated .
3. Always consult 3-Chlorophenylacetic acid the specific Safety Data Sheet (SDS) for 3-Chlorophenylacetic acid for complete hazard information, first-aid procedures, and handling instructions; precautionary statements include P261 (avoid breathing dust), P264 (wash skin thoroughly after handling), and P280 (wear protective gloves/eye protection) . Some sources classify it as not hazardous for transport , while others assign UN2811 .