Diisopropyl Azodicarboxylate CAS 2446-83-5

1. Diisopropyl azodicarboxylate is a key reagent in the Mitsunobu reaction, serving as an oxidizer of triphenylphosphine and enabling the conversion of alcohols to various esters, including its use in synthesizing hepatitis C virus inhibitors and PPAR agonists . It is preferred over diethyl azodicarboxylate (DEAD) in some cases due to its steric bulk, which minimizes the formation of hydrazide byproducts .
2. Diisopropyl azodicarboxylate CAS 2446-83-5 is widely used in the pharmaceutical industry for drug synthesis, such as in the preparation of Bruton's tyrosine kinase inhibitors, chromenes resembling classical cannabinoids, and hydrazinophosphonates . It also acts as an intermediate in producing photosensitizers, polymer catalysts, and as a selective deprotecting agent for N-benzyl groups .
3. Applications of Diisopropyl azodicarboxylate also include its use in aza-Baylis-Hillman reactions with acrylates to form adducts, and in polymer material synthesis where it can initiate polymerization through free radical formation .

1. Store Diisopropyl azodicarboxylate in a tightly sealed container under an inert gas (e.g., argon) in a cool, dry, well-ventilated place; recommended storage temperature is 2-8°C (refrigerated) to prevent decomposition, and it must be protected from light .
2. Keep Diisopropyl azodicarboxylate strictly away from strong oxidizing agents, strong bases, and alcohols, as it is incompatible with these materials. Diisopropyl azodicarboxylate CAS 2446-83-5 should also be isolated from heat, sparks, and open flames . As a UN-classified self-reactive substance, it poses a risk of self-accelerating decomposition if shocked, rubbed, or exposed to temperatures above 80-100°C, potentially leading to thermal runaway .
3. Always use appropriate personal protective equipment (PPE) including butyl-rubber gloves, safety goggles, protective clothing, and work in a fume hood with explosion-proof equipment to avoid breathing vapors, mist, or gas, and to prevent skin and eye contact .

1. Immediately isolate the spill area, eliminate all ignition sources, and ensure adequate ventilation. Contain Diisopropyl azodicarboxylate using inert, non-combustible absorbent material (e.g., sand, vermiculite) and prevent entry into drains or waterways .
2. Carefully collectDiisopropyl azodicarboxylate CAS 2446-83-5 using non-sparking tools into sealed, labeled corrosion-resistant chemical waste containers for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear full chemical-protective equipment including self-contained breathing apparatus (SCBA) during cleanup. Do NOT allow runoff from fire control or dilution water to cause pollution .

1. Diisopropyl azodicarboxylate is classified as a combustible liquid (flash point 100-106°C) and causes skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335) . It is suspected of causing cancer (H351) and may cause damage to organs through prolonged or repeated exposure (H373) . Signal word is "Warning" .
2. Diisopropyl azodicarboxylate is toxic to aquatic life with long lasting effects (H411) and is not readily biodegradable . It decomposes violently above 100°C, releasing toxic fumes including nitrogen oxides and carbon monoxide; it can form explosive mixtures with air on intense heating and has an NFPA health rating of 2 (moderate hazard) . LD50 values include inhalation LC50 (rat) >12,000 mg/L/8h and dermal LD50 (rabbit) 2,150 mg/kg .
3. Always consult Diisopropyl azodicarboxylate CAS 2446-83-5 the specific Safety Data Sheet (SDS) for Diisopropyl azodicarboxylate for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P303+P361+P353 for skin, P301+P330+P331 for ingestion), and handling instructions. Precautionary statements include P260 (do not breathe vapors), P273 (avoid release to environment), P280 (wear protective gloves/eye protection), and P405 (store locked up). Transport classification may vary (UN3082 or not regulated for domestic transport) .