Tert-Butyl Bromoacetate CAS 5292-43-3

1. tert-Butyl bromoacetate CAS 5292-43-3 is widely used as an alkylating agent and key intermediate in organic synthesis for producing pharmaceuticals, agrochemicals, dyes, and various organic compounds . Tert-Butyl bromoacetate plays an important role in the synthesis of collagenase inhibitors and (2-oxo-4-vinyl-azetidin-1-yl)-acetic acid tert-butyl ester .
2. The compound serves as a versatile building block in medicinal chemistry, used in the synthesis of aldose reductase inhibitors for diabetes research , bifunctional chelating agents for radiopharmaceuticals , and pseudodipeptide building blocks for peptide drug modification .
3. Applications of tert-Butyl bromoacetate also include its use in polymer chemistry for synthesizing functionalized polymers and as a starting reagent for N-substituted oligoglycines (peptoids) and N-Oxalylglycine derivatives .

1. Store tert-Butyl bromoacetate CAS 5292-43-3 in a tightly sealed container under an inert gas (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperatures vary from refrigeration (2-8°C) to a cool, dark place below 15°C, as it is hygroscopic and decomposes in moist air .
2. Keep tert-Butyl bromoacetate strictly away from strong oxidizing agents and strong bases due to incompatibility . Protect from heat, sparks, and open flames as it is a flammable liquid with a flash point of 49°C (120°F) .
3. Always Tert-Butyl bromoacetate use appropriate personal protective equipment (PPE) including chemical-resistant gloves (butyl-rubber or nitrile recommended), tightly fitting safety goggles, face shield, and protective clothing. Handle only in a chemical fume hood with explosion-proof equipment to avoid breathing vapors and prevent skin/eye contact .

1. Immediately isolate the spill area, eliminate all ignition sources, and provide adequate ventilation. Contain tert-Butyl bromoacetate CAS 5292-43-3 using inert, non-combustible absorbent material and absolutely prevent entry into drains or waterways .
2. Carefully collect Tert-Butyl bromoacetate using non-sparking tools or an explosion-proof vacuum into a sealed, labeled, corrosion-resistant chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear full chemical-protective equipment including self-contained breathing apparatus (SCBA) during cleanup. tert-Butyl bromoacetate is classified for transport.

1. Tert-Butyl bromoacetate CAS 5292-43-3 is classified as a flammable liquid and vapor (H226) and is corrosive, causing severe skin burns and serious eye damage (H314/H318). Tert-Butyl bromoacetate is harmful if swallowed (H302) with an oral LD50 of 400 mg/kg in rats, and may cause respiratory irritation (H335) .
2. tert-Butyl bromoacetate reacts with water and is incompatible with strong oxidizing agents and bases. Vapors are heavier than air and may form explosive mixtures. Thermal decomposition produces toxic and corrosive fumes including carbon monoxide, carbon dioxide, and hydrogen bromide gas . The GHS signal word is "Danger" .
3. Always consult the specific Safety Data Sheet (SDS) for tert-Butyl bromoacetate for complete hazard information, first-aid procedures, and handling instructions. Precautionary statements include P210 (keep away from heat/sparks/open flames), P233 (keep container tightly closed), and P280 (wear protective gloves/eye protection) .