2-Aminonicotinic Acid CAS 5345-47-1

1. 2-Aminonicotinic acid CAS 5345-47-1 is widely utilized as a key heterocyclic building block in pharmaceutical development, particularly in the synthesis of drugs targeting neurological disorders, as well as novel anti-inflammatory and anti-cancer agents .
2. 2-Aminonicotinic acid serves as a crucial precursor for creating pyrido[2,3-d]pyrimidine derivatives and other fused heterocyclic systems, which are valuable scaffolds in drug discovery, and is used to prepare metal complexes with Co(II), Ni(II), Cu(II), and Zn(II) that exhibit antibacterial, fungicidal, and nematicidal activities in research settings .
3. 2-Aminonicotinic acid is employed in biochemical research for enzyme inhibition and receptor binding studies to understand biological pathways, and its derivatives have been investigated in silico as potential cyclooxygenase (COX) inhibitors for developing anti-inflammatory agents .
4. Researchers utilize 2-Aminonicotinic acid in agricultural chemistry for creating new agrochemicals, in material science for developing polymers and coatings with improved properties, and in analytical chemistry as a reagent for detecting and quantifying other compounds in complex mixtures .

1. 2-Aminonicotinic acid CAS 5345-47-1 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment; recommended storage temperatures range from 0-8°C (refrigerator) for short-term stability, with powder stable for up to 36 months at 2-8°C .
2. 2-Aminonicotinic acid is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" according to ECHA C&L Inventory notifications .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and minimizing dust generation and accumulation .
4. Keep away from incompatible materials such as strong oxidizing agents to prevent decomposition; wash thoroughly after handling; the compound is stable under normal temperatures and pressures, with a melting point of 295-297°C (dec.) and pKa of 2.94 .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator (type N95 or P1 filter) when 2-aminonicotinic acid CAS 5345-47-1 is released .
2. Clean up spills 2-Aminonicotinic acid immediately by sweeping or vacuuming without creating dust using non-sparking tools, then place into suitable closed containers for disposal, avoiding generation of dusty conditions .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses as discharge into the environment must be avoided (WGK Germany 3 - high water hazard potential) .
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration; note that the substance has UNII S29G45VTQ6 and is not classified as dangerous goods for transport .

1. 2-Aminonicotinic acid CAS 5345-47-1 is combustible with a flash point not applicable (solid), density of 1.545 g/cm³, and decomposes at approximately 297°C; under fire conditions, hazardous decomposition products include toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide, and irritating gases .
2. Use 2-Aminonicotinic acid water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product, selecting the extinguishing media most appropriate to the surrounding materials .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 2-aminonicotinic acid due to hazardous decomposition gases generated by thermal decomposition or combustion .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination and pollution .