2-Amino-6-chloropyridine CAS 45644-21-1

1. 2-Amino-6-chloropyridine is a key heterocyclic building block primarily used in pharmaceutical development as an intermediate for synthesizing drugs targeting neurological disorders, as well as compounds with antibacterial, antitumor, and antiviral activities .
2. 2-Amino-6-chloropyridine CAS 45644-21-1 serves as a versatile intermediate in organic synthesis, participating in important reactions such as Suzuki coupling to generate heterocyclic compounds with potential biological activity, and undergoing regioselective bromination to introduce a bromine atom para to the amino group .
3. 2-Amino-6-chloropyridine is employed as a starting material for synthesizing novel imidazopyridine nucleoside derivatives designed as Maribavir analogues for antiviral research, and in the formation of various heterocyclic systems including pyrazolopyridines and pyridopyrimidines .
4. Researchers utilize this compound in agrochemical formulation for developing herbicides and fungicides, in material science for creating polymers and coatings with specific properties, and as a substrate in nickel-catalyzed homocoupling reactions .

1. 2-Amino-6-chloropyridine must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment; recommended storage conditions range from 0-8°C to room temperature (Keep in dark place, sealed in dry conditions) depending on stability requirements .
2. 2-Amino-6-chloropyridine CAS 45644-21-1 is classified with GHS hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .
4. Keep away from incompatible materials such as strong oxidizing agents to prevent decomposition; wash thoroughly after handling, and note that the compound has acute oral toxicity (LD50) of 680 mg/kg in rats .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator (type N95 or P1 filter) when 2-amino-6-chloropyridine is released .
2. Collect 2-Amino-6-chloropyridine CAS 45644-21-1 by sweeping or vacuuming without creating dust using non-sparking tools, or absorb with inert materials, and place into suitable closed containers for disposal, taking care not to disperse the powder .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses as it is slightly hazardous to water (WGK Germany 3) .
4. Dispose of collected 2-Amino-6-chloropyridine CAS 45644-21-1 material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. 2-Amino-6-chloropyridine is combustible with a flash point of approximately 108.5°C, melting point of 69-73°C, and boiling point of 255.7°C at 760 mmHg; under fire conditions, hazardous decomposition products include toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and hydrogen chloride .
2. Use dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray to extinguish fires involving the product; do NOT use a direct water jet as it may scatter burning material .
3. Firefighters 2-Amino-6-chloropyridine CAS 45644-21-1 should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 2-amino-6-chloropyridine due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination and pollution .