2-Cyanopyrimidine CAS 14080-23-0

1. 2-Cyanopyrimidine is primarily utilized as a key intermediate in pharmaceutical synthesis, particularly for developing antiviral, antibacterial, and anticancer agents, and is a crucial building block for the drug bosentan .
2. 2-Cyanopyrimidine CAS 14080-23-0 functions as a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM, making it valuable for research into osteoporosis and arthritis where cathepsin K activity is linked to bone resorption .
3. 2-Cyanopyrimidine is employed in cutting-edge biochemical research as a linker for the N-terminal selective macrocyclization of phage-displayed peptides, enabling the identification of potent peptide ligands such as Z27S1 which binds to the ZNRF3 extracellular domain with a KD of 360 nM .
4. Researchers utilize 2-Cyanopyrimidine CAS 14080-23-0 in agrochemical formulation for herbicides and fungicides, as a building block for fine chemicals and material science R&D, and as a reagent in analytical chemistry for detecting other substances in complex mixtures .

1. 2-Cyanopyrimidine must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light, with recommended storage at room temperature (in a dark, dry place), 2-8°C, or -20°C for long-term stability depending on the source .
2. 2-Cyanopyrimidine CAS 14080-23-0 is classified as a dangerous substance with GHS signal word "Danger" and hazard statements including H301 (Toxic if swallowed), H315 (Causes skin irritation), H317 (May cause allergic skin reaction), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation) .
3. Personnel must wear chemical-resistant nitrile rubber gloves (minimum 0.11 mm thickness, breakthrough time 480 min), safety goggles with side-shields, face protection, and complete chemical protective suit when handling this substance, ensuring adequate ventilation and avoiding dust and aerosol formation .
4. Keep away from incompatible materials such as strong oxidizing agents to prevent hazardous reactions; wash hands thoroughly after handling, do not eat, drink, or smoke when using, and follow precautionary statements P261, P264, P270, P271, P280, P301+P310, and P305+P351+P338 .

1. Isolate the spill area, ensure adequate ventilation, evacuate personnel to safe areas, and wear full personal protective equipment including NIOSH/MSHA-approved respirator when 2-cyanopyrimidine is released .
2. Collect 2-Cyanopyrimidine CAS 14080-23-0 by sweeping or shoveling without creating dust using non-sparking tools, and place into suitable closed containers for disposal; avoid breathing dust and prevent further leakage or spillage if safe to do so .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure, decontaminate surfaces using appropriate methods, and prevent the product from entering drains or water courses due to potential environmental hazards .
4. Dispose of collected 2-Cyanopyrimidine CAS 14080-23-0 material as hazardous waste through licensed chemical destruction or controlled incineration in a chemical incinerator equipped with an afterburner and scrubber, in accordance with local, state, and federal environmental regulations .

1. 2-Cyanopyrimidine is combustible with a flash point >110°C (closed cup) and NFPA health rating of 3 (short exposure could cause serious temporary or moderate residual injury); under fire conditions, hazardous decomposition products include carbon oxides and nitrogen oxides (NOx) .
2. Use 2-Cyanopyrimidine CAS 14080-23-0 water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide to extinguish fires involving the product .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 2-cyanopyrimidine due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray, and contain fire runoff to prevent environmental contamination and pollution .