2-Methyl-4-Isothiazolin-3-one / MIT CAS 2682-20-4

1. 2-Methyl-4-isothiazolin-3-one (MIT) is a highly effective, broad-spectrum biocide and preservative used in personal care products such as shampoos, conditioners, body washes, lotions, and facial cleansers to prevent microbial growth and extend shelf life . It is approved for use in rinse-off products at a maximum concentration of 100 ppm (0.01%) .
2. MIT CAS 2682-20-4 serves as a preservative in industrial applications including adhesives, coatings, paints, metalworking fluids, resin emulsions, fuels, and wood products, where it prevents spoilage by controlling bacteria, fungi, and algae .
3. In industrial process water systems, MIT is used to control slime-forming bacteria and algae in pulp/paper mills, cooling water systems, oil field operations, and air washer systems .
4. The compound is employed as an antimicrobial preservative in household cleaning products, including detergents, laundry detergents, wet wipes, and disinfectants . In combination with 5-chloro-2-methyl-4-isothiazolin-3-one (CIT) or benzisothiazolinone (BIT), synergistic antimicrobial activity is achieved at lower concentrations .

1. 2-Methyl-4-isothiazolin-3-one must be stored in a tightly sealed container in a cool, dry, well-ventilated area, protected from light and moisture; recommended storage at 2-8°C (refrigerated) .
2. MIT CAS 2682-20-4 is classified with GHS hazard statements H301+H311 (Toxic if swallowed or in contact with skin), H314 (Causes severe skin burns and eye damage), H317 (May cause an allergic skin reaction), H330 (Fatal if inhaled), and H410 (Very toxic to aquatic life with long-lasting effects), with signal word "Danger" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance; avoid breathing mists or vapors and ensure adequate ventilation in work areas. MIT CAS 2682-20-4 is a known skin sensitizer and can cause allergic contact dermatitis .
4. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases to prevent decomposition. Avoid release to the environment due to high aquatic toxicity .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable respirator (NIOSH-approved) when cleaning up MIT .
2. Collect MIT CAS 2682-20-4 by absorbing with inert absorbent materials such as sand, vermiculite, or diatomaceous earth using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating splashes or mists during cleanup to prevent skin and eye exposure; prevent the product from entering drains, sewers, or water courses due to high aquatic toxicity .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical disposal facilities. Contaminated packaging should be triple-rinsed and disposed of as hazardous waste .

1. 2-Methyl-4-isothiazolin-3-one has a flash point of 93°C and is not classified as highly flammable, but will decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides, and sulfur oxides .
2. Use dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray to extinguish fires involving the product. Do not use a direct water jet as MIT CAS 2682-20-4 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus (SCBA) in pressure-demand, NIOSH-approved, and full protective gear when handling fires involving this compound due to hazardous decomposition gases generated during thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination. Avoid release of extinguishing water into drains or water courses due to aquatic toxicity .