Hypericin CAS 548-04-9

1. Hypericin is a naturally occurring naphthodianthrone found in St. John's Wort (*Hypericum perforatum*), primarily used in research for its potent antiviral activity against enveloped viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and SARS-CoV-2 .
2. Hypericin CAS 548-04-9 functions as a photosensitizer in photodynamic therapy (PDT) for treating certain cancers and skin conditions; upon light activation, Hypericin generates reactive oxygen species (ROS) that induce apoptosis in abnormal cells, showing efficacy in cutaneous T-cell lymphoma (CTCL) and other tumors .
3. Hypericin exhibits significant anti-inflammatory and immunomodulatory effects by modulating key signaling pathways such as NF-κB and MAPK, making Hypericin a candidate for research into autoimmune and inflammatory skin conditions like psoriasis and atopic dermatitis .
4. Beyond antiviral and antitumor applications, Hypericin is studied for its antidepressant properties via neurotransmitter modulation, as well as for its inhibitory effects on enzymes such as monoamine oxidase (MAO), protein kinase C (PKC), and topoisomerase II .

1. Hypericin is highly light-sensitive and must be stored in a tightly sealed, light-protected container; for long-term stability, it is recommended to store Hypericin powder at -20°C, protected from light and moisture .
2. For Hypericin CAS 548-04-9 solution storage, prepare aliquots of Hypericin in tightly sealed vials and store at -20°C for up to 1 month or at -80°C for up to 6 months, avoiding repeated freeze-thaw cycles to prevent degradation .
3. Hypericin is a moderate to severe irritant to the skin and eyes; personnel must wear chemical-resistant rubber gloves, safety goggles, and protective clothing when handling Hypericin .
4. Hypericin is toxic if swallowed and may cause photosensitivity reactions upon exposure to sunlight; keep Hypericin away from strong oxidizing agents, and note that thermal decomposition of Hypericin may produce toxic fumes such as carbon monoxide, carbon dioxide, and nitrogen oxides .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when Hypericin is released .
2. Collect the spilled Hypericin CAS 548-04-9 by sweeping or vacuuming without creating dust using non-sparking tools, and place the product into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol, and prevent Hypericin from entering drains or water courses .
4. Dispose of collected Hypericin according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. Hypericin is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use Hypericin CAS 548-04-9 water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving Hypericin .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Hypericin due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, Hypericin may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .