5'-Deoxy-5-fluorocytidine CAS 66335-38-4

1. 5'-Deoxy-5-fluorocytidine (5'-DFCR) is a key intermediate metabolite in the activation pathway of the oral anti-cancer prodrug capecitabine, which is converted from capecitabine by carboxylesterase primarily in the liver .
2. 5'-Deoxy-5-fluorocytidine CAS 66335-38-4 is subsequently metabolized by cytidine deaminase to form 5'-deoxy-5-fluorouridine (5'-DFUR), which is then converted to the active anti-cancer agent 5-fluorouracil (5-FU) by thymidine phosphorylase, an enzyme preferentially located in tumor tissues .
3. 5'-Deoxy-5-fluorocytidine is widely used in pharmaceutical research and development as a reference standard, as an intermediate for synthesizing capecitabine, and as a research tool for studying fluoropyrimidine metabolism and enzyme kinetics .
4. Researchers utilize 5'-Deoxy-5-fluorocytidine CAS 66335-38-4 as an analytical standard for quantifying capecitabine metabolites in pharmacokinetic studies and clinical samples using LC-MS and HPLC methods .

1. 5'-Deoxy-5-fluorocytidine must be stored in a tightly sealed container at refrigerated temperatures (2-8°C) for long-term stability, protected from light and moisture .
2. For maximum stability, long-term storage is recommended at -20°C, while short-term storage at room temperature is acceptable only for brief periods . Solutions should be stored at -20°C and used within 30 days .
3. 5'-Deoxy-5-fluorocytidine CAS 66335-38-4 is classified as harmful if swallowed (Xn, R22) with hazard statements indicating potential irritation to eyes, respiratory system, and skin (Xi, R36/37/38) . The toxicological properties have not been fully investigated, so appropriate precautions should be taken .
4. Personnel must wear chemical-resistant rubber gloves, NIOSH/MSHA-approved respirators, chemical safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator (type N95 or P1 filter) when 5'-Deoxy-5-fluorocytidine is released .
2. Collect 5'-Deoxy-5-fluorocytidine CAS 66335-38-4 by sweeping or vacuuming without creating dust using non-sparking tools; for spills involving solutions, absorb with inert liquid-binding materials such as diatomite or universal binders, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol; prevent 5'-Deoxy-5-fluorocytidine CAS 66335-38-4 from entering drains or water courses as discharge into the environment must be avoided .
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration with flue gas scrubbing .

1. 5'-Deoxy-5-fluorocytidine is not classified as highly flammable (flash point approximately 218.6°C, boiling point 437.9°C) but may decompose under fire conditions . During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion .
2. Use water spray, dry chemical powder, alcohol-resistant foam, or carbon dioxide to extinguish fires involving the product; do NOT use a direct water jet as 5'-Deoxy-5-fluorocytidine CAS 66335-38-4 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 5'-Deoxy-5-fluorocytidine due to hazardous decomposition gases generated by thermal decomposition .
4. Hazardous decomposition products formed under fire conditions include toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and hydrogen fluoride . During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination and pollution .