D-Serine CAS 312-84-5

1. D-Serine CAS 312-84-5 is primarily used in biomedical research as an endogenous co-agonist at the N-methyl-D-aspartate (NMDA) receptor, playing a critical role in glutamatergic neurotransmission, synaptic plasticity, and cognitive function .
2. D-Serine is investigated as a therapeutic candidate for neurological and psychiatric disorders, including schizophrenia (based on the glutamate hypofunction hypothesis), cognitive enhancement, Parkinson's disease, and post-traumatic stress disorder (PTSD) .
3. D-Serine serves as a gliotransmitter (or gliomodulator) synthesized from L-serine by the enzyme serine racemase, predominantly in astrocytes, and is degraded by D-amino acid oxidase (DAAO), making it a key tool for studying glial-neuronal interactions .
4. Researchers utilize D-Serine as an essential research biochemical for in vitro and in vivo studies investigating NMDA receptor pharmacology, synaptic transmission, and the pathophysiology of disorders involving hypoglutamatergic states .

1. D-Serine CAS 312-84-5 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment; powder form is stable for up to 3 years at -20°C, 2 years at 4°C, or 12 months at +4°C under desiccating conditions .
2. For solution storage, prepare aliquots in tightly sealed vials; stock solutions are stable for up to 6 months at -80°C or 1 month at -20°C. Avoid repeated freeze-thaw cycles .
3. D-Serine is generally not classified as a hazardous substance under GHS criteria, but precautionary measures include wearing chemical-resistant gloves, safety goggles with side-shields, and protective clothing to avoid dust and aerosol formation .
4. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases; maintain adequate ventilation in work areas and wash thoroughly after handling .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when D-Serine CAS 312-84-5 is released .
2. Collect D-Serine by sweeping or vacuuming without creating dust using non-sparking tools, or absorb solutions with inert liquid-binding materials such as diatomite or universal binders, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol; prevent the product from entering drains or water courses as discharge into the environment should be avoided .
4. Dispose of collected D-Serine material according to local, state, and federal environmental regulations; the substance is considered non-hazardous for transport (IATA, IMDG, DOT) but should be treated as research chemical waste .

1. D-Serine CAS 312-84-5 is not classified as highly flammable but may decompose under fire conditions, with a flash point of approximately 53°C (lit.) and a melting point of 220-240°C (dec.) .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as D-Serine CAS 312-84-5 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning D-Serine due to hazardous decomposition gases generated by thermal decomposition .
4. Hazardous decomposition products formed under fire conditions include toxic fumes of carbon monoxide, carbon dioxide, and nitrogen oxides (NOx); during combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .