7 8-Dihydroxyflavone CAS 38183-03-8

1. 7,8-Dihydroxyflavone is a naturally occurring flavonoid primarily used as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB), mimicking the effects of brain-derived neurotrophic factor (BDNF) .
2. 7 8-Dihydroxyflavone CAS 38183-03-8 has demonstrated significant neuroprotective and neurorestorative effects in preclinical models of neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's disease, and spinal cord injury, where it activates TrkB signaling pathways without inducing an immune response .
3. 7,8-Dihydroxyflavone is employed in metabolic research to study its effects on brown adipose tissue (BAT) activity, showing improved glucose tolerance and protection against high-fat diet-induced metabolic abnormalities through TrkB-dependent mechanisms .
4. In material science and pharmaceutical formulation research, 7,8-dihydroxyflavone is used to develop nanoparticle-based delivery systems (e.g., DSPE-PEG2000 nanoparticles) to enhance its poor water solubility and improve bioavailability for therapeutic applications .

1. 7,8-Dihydroxyflavone powder must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment; powder is stable for up to 3 years at -20°C or 2 years at 4°C .
2. For solution storage, prepare aliquots in tightly sealed vials and store at -20°C for up to 1 month or at -80°C for up to 6 months, avoiding repeated freeze-thaw cycles to prevent degradation .
3. 7 8-Dihydroxyflavone CAS 38183-03-8 is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" .
4. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 7,8-Dihydroxyflavone is released .
2. Collect 7 8-Dihydroxyflavone CAS 38183-03-8 by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses as discharge into the environment should be avoided .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. 7,8-Dihydroxyflavone is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as 7 8-Dihydroxyflavone CAS 38183-03-8 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 7,8-Dihydroxyflavone due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, and contain fire runoff to prevent environmental contamination .