DL-Norvaline CAS 760-78-1

1. DL-Norvaline CAS 760-78-1 is a non-proteinogenic amino acid used as a substrate in biochemical research to study the specificity of enzymes that metabolize natural branched-chain amino acids .
2. DL-Norvaline has demonstrated the ability to reduce microglial activation and decrease the expression of pro-inflammatory cytokines such as TNF-α, IL-6, and COX-2 in preclinical models, indicating potential for research into neuroinflammatory conditions .
3. DL-Norvaline is employed as a building block in peptide synthesis for preparing analogs of natural peptides, and serves as an internal standard in analytical chemistry for amino acid analysis .
4. The antialgal activity of DL-Norvaline has been investigated, where it causes reversible inhibition of the growth of *Chlamydomonas reinhardtii* by acting as an antagonist of the arginine metabolic pathway .

1. DL-Norvaline CAS 760-78-1 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment; powder is stable for up to 3 years at -20°C or 2 years at 4°C .
2. DL-Norvaline is classified with hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .
4. Keep away from incompatible materials such as strong oxidizing agents; for solution storage, prepare aliquots and use within 1 month at -20°C, avoiding repeated freeze-thaw cycles .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when DL-Norvaline CAS 760-78-1 is released .
2. Collect DL-Norvaline by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. DL-Norvaline CAS 760-78-1 is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides.
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as DL-Norvaline may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning DL-Norvaline due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, and contain fire runoff to prevent environmental contamination .