Magnolol CAS 528-43-8

1. Magnolol is a polyphenolic neolignan isolated from the root and stem bark of *Magnolia officinalis*, exhibiting a wide range of biological activities including anti-inflammatory, antioxidant, antimicrobial, anticancer, and neuroprotective effects .
2. Magnolol CAS 528-43-8 functions as a dual agonist of RXRα and PPARγ and demonstrates potent antifungal activity against *Fusarium* species and antibacterial effects against Gram-positive and Gram-negative bacteria .
3. In materials science, magnolol is used as a renewable bio-based building block for synthesizing intrinsic flame-retardant epoxy resins and phosphonate flame retardants with enhanced thermal stability and combustion behavior .
4. Researchers Magnolol CAS 528-43-8 utilize magnolol in studies of neurological disorders (Alzheimer's and Parkinson's disease), metabolic regulation, and cardiovascular protection, as well as in the development of derivatives with improved water solubility and bioavailability .

1. Magnolol powder must be stored in a tightly sealed container at 2-8°C (refrigerated) in a cool, dry, and well-ventilated environment, protected from light and moisture; under these conditions, it is stable for up to 2 years .
2. For solution storage (stock solutions), prepare aliquots in tightly sealed vials and store at -20°C for up to 1 month or at -80°C for up to 6 months, avoiding repeated freeze-thaw cycles to prevent degradation .
3. Magnolol CAS 528-43-8 is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye injury), and H335 (May cause respiratory irritation), with signal word "Danger" .
4. Personnel must wear chemical-resistant gloves (nitrile rubber), safety goggles with side-shields (type N95 or equivalent), and protective clothing when handling Magnolol, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when Magnolol is released .
2. Collect Magnolol CAS 528-43-8 by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol .
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. Magnolol is classified as a combustible solid (Storage Class 11) and may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as Magnolol CAS 528-43-8 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Magnolol due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination .