Acetylaconitine CAS 77181-26-1

1. Acetylaconitine is a diterpenoid alkaloid isolated from *Aconitum flavum* and other Aconitum species, primarily used in pharmacological research for its potent analgesic activity, which is 5.1-35.6 times that of morphine and 1250-3912 times that of aspirin .
2. Acetylaconitine CAS 77181-26-1 serves as an NF-κB inhibitor and has demonstrated cytotoxic activity against cancer cells, with an IC50 of 18.6 µM against P388 leukemia cells .
3. Acetylaconitine is employed in studies of cardiovascular pharmacology, where it induces arrhythmia in isolated guinea pig atria at concentrations of 60-100 nM and causes a decline in blood pressure and myocardial contraction .
4. Researchers utilize Acetylaconitine CAS 77181-26-1 to investigate structure-toxicity relationships of aconitine-type alkaloids, where its toxicity (LD50) is lower than aconitine but still significant, and its analgesic effect is antagonized by naloxone and eliminated by reserpine .

1. Acetylaconitine powder must be stored in a tightly sealed container at -20°C for long-term stability (up to 3 years), protected from light and moisture; in solvent, storage at -80°C for up to 1 year is recommended .
2. Acetylaconitine CAS 77181-26-1 is classified as a highly toxic substance (acute oral toxicity Category I) with an LD50 of approximately 0.16 mg/kg (i.v.) in mice and 0.28 mg/kg (i.v.) in rats .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and impervious protective clothing when handling acetylaconitine; avoid formation of dust and aerosols, and work only in well-ventilated areas (preferably a chemical fume hood) .
4. Acetylaconitine is incompatible with strong oxidizing agents and should be kept away from heat, sparks, and open flames; it is a moderate eye and skin irritant with hepatotoxicity and respiratory toxicity concerns .

1. Isolate the spill area immediately, ensure adequate ventilation, and wear full personal protective equipment including self-contained breathing apparatus (SCBA), chemical-resistant gloves, and safety goggles when acetylaconitine is released .
2. For solid spills, collect Acetylaconitine CAS 77181-26-1 by sweeping or vacuuming without creating dust using non-sparking tools; absorb solutions with inert materials such as sand, diatomite, or universal binders, and place into suitable closed containers for disposal .
3. Avoid creating dust or vapor clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol .
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations; prevent acetylaconitine from entering drains or water courses due to its high aquatic toxicity .

1. Acetylaconitine is not classified as highly flammable (flash point not applicable for solid) but is a combustible solid (Storage Class 11) that may decompose under fire conditions .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as Acetylaconitine CAS 77181-26-1 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning acetylaconitine due to hazardous decomposition gases generated by thermal decomposition .
4. Hazardous decomposition products formed under fire conditions include carbon monoxide, carbon dioxide, and nitrogen oxides (NOx); contain fire runoff to prevent environmental contamination .