Chelidonic Acid CAS 99-32-1

1. Chelidonic acid is a naturally occurring γ-pyrone derivative primarily used in biomedical research for its diverse pharmacological properties, including antioxidant, anti-inflammatory, immunomodulatory, neuroprotective, cardioprotective, and nephroprotective effects .
2. Chelidonic acid CAS 99-32-1 functions as a glutamate decarboxylase inhibitor with a Ki of 1.2 μM, and has been shown to suppress pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β while modulating key signaling pathways including Nrf2, AMPK, and NF-κB .
3. Chelidonic acid is employed in studies of chemotherapy-induced toxicities, demonstrating protective effects against paclitaxel-induced peripheral neuropathy, doxorubicin-induced cardiotoxicity, and cisplatin-induced nephrotoxicity in preclinical models .
4. Researchers utilize Chelidonic acid CAS 99-32-1 as a biochemical reagent and building block in organic synthesis, particularly for thermal decarboxylation reactions to produce 4-pyrone derivatives .

1. Chelidonic acid powder must be stored in a tightly sealed container at -20°C for long-term stability (up to 3 years), or at 2-8°C for short-term storage, protected from light and moisture .
2. For solution storage, prepare aliquots in tightly sealed vials and store at -20°C for up to 3-6 months, avoiding repeated freeze-thaw cycles to prevent loss of potency .
3. Chelidonic acid CAS 99-32-1 is classified with GHS signal word "Warning" and hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation) .
4. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling Chelidonic acid, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when Chelidonic acid is released .
2. Collect Chelidonic acid CAS 99-32-1 by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses as it has WGK Germany 3 classification (high water hazard potential) .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. Chelidonic acid is a combustible solid (Storage Class 11) with a melting point of 265°C (decomposition), and may decompose under fire conditions emitting toxic fumes .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as Chelidonic acid CAS 99-32-1 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Chelidonic acid due to hazardous decomposition gases generated by thermal decomposition .
4. Hazardous decomposition products formed under fire conditions include carbon monoxide and carbon dioxide; contain fire runoff to prevent environmental contamination .