Punicalagin CAS 65995-63-3

1. Punicalagin CAS 65995-63-3 is a hydrolyzable ellagitannin and the primary bioactive polyphenol found in pomegranate (Punica granatum) peel, accounting for a significant portion of its antioxidant activity .
2. The compound has demonstrated a wide range of pharmacological activities in research, including anti-inflammatory, antioxidant, anti-cancer, antibacterial, antiviral, and cardioprotective effects .
3. It functions by inhibiting inflammatory enzymes and oxidative stress pathways; it is also a non-competitive inhibitor of 3CLpro, showing potential in research against SARS-CoV-2 replication .
4. Researchers utilize this compound in studies investigating its antibacterial mechanisms (such as disrupting bacterial membranes and biofilms), its synergistic effects with antibiotics like oxacillin against MRSA, and its ability to lower LDL cholesterol by enhancing LDL receptor expression .

1. Punicalagin CAS 65995-63-3 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and heat; recommended storage is at -20°C for long-term stability (up to 3 years) or at 2-8°C for up to 2 years .
2. Punicalagin is classified as a moderate to severe irritant to the skin and eyes; it contains a pharmaceutically active ingredient and handling should only be performed by trained personnel .
3. Personnel must wear chemical-resistant rubber gloves, NIOSH/MSHA-approved respirators, chemical safety goggles with side-shields, and impervious protective clothing when handling Punicalagin .
4. Punicalagin is stable when stored as directed but should be kept away from incompatible materials such as strong oxidizing agents; for solution storage, prepare aliquots and use within 1 month at -20°C, avoiding repeated freeze-thaw cycles .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including self-contained breathing apparatus, chemical-resistant gloves, and chemical safety goggles when Punicalagin CAS 65995-63-3 is released .
2. Collect Punicalagin by sweeping or vacuuming without creating dust using non-sparking tools; for liquid spills, absorb with finely-powdered liquid-binding materials such as diatomite or universal binders .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations; the substance is considered non-hazardous for transport.

1. Punicalagin CAS 65995-63-3 is not classified as highly flammable but may decompose under fire conditions; it emits toxic fumes such as carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) during thermal decomposition .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as Punicalagin may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Punicalagin due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination .