Glyceryl Monooleate CAS 111-03-5

1. Glyceryl monooleate CAS 111-03-5 is a non-ionic surfactant and emulsifier widely used in the food industry as an anti-caking agent, drying agent, emulsifier, and flavoring adjuvant to stabilize emulsions and improve texture in products like shortenings, bakery mixes, and icings .
2. Glyceryl Monooleate is a key lipid component in advanced drug delivery systems, particularly for forming cubosomes and other nanostructured carriers that enhance the solubility and transdermal permeation of poorly water-soluble drugs such as paclitaxel and tizanidine .
3. Glyceryl monooleate serves as a pharmaceutical excipient and permeation enhancer, used to improve the bioavailability of active pharmaceutical ingredients, and is available as a certified reference material for quality control and analytical method development .
4. In industrial applications, Glyceryl Monooleate functions as a dispersing or solubilizing agent for flavors, essential oils, and vitamins, and is also utilized as a lubricant and defoaming agent in food processing .

1. Glyceryl monooleate CAS 111-03-5 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment; the pure compound should be kept at -10 to -25°C, while industrial solutions in hexane require ambient storage (>5°C) with strict flammability precautions .
2. Glyceryl Monooleate is sensitive to air, light, and oxidation; long-term storage under inert gas (e.g., nitrogen) in a dark, dry place is recommended to prevent degradation .
3. Personnel handling Glyceryl monooleate should wear chemical-resistant gloves, safety goggles, and protective clothing, as the compound may cause skin and eye irritation; industrial grade formulations in organic solvents may present serious health hazards, including narcotic effects and reproductive toxicity .
4. Keep away from heat, sparks, and incompatible materials such as strong oxidizing agents; in industrial formulations, ensure proper ventilation and use explosion-proof equipment to manage flammable solvent vapors .

1. Isolate the spill area immediately, ensure adequate ventilation, and remove all sources of ignition; wear full personal protective equipment including chemical-resistant gloves, safety goggles, and appropriate respiratory protection (NIOSH/MSHA-approved respirator with multi-purpose cartridges) .
2. For solid or Glyceryl Monooleate spills, contain the product using non-sparking tools, absorb with inert materials such as sand, diatomite, or universal binders, and collect into suitable closed containers for disposal .
3. Avoid creating dust or vapor clouds during cleanup to prevent respiratory exposure; for spills involving flammable solvents, use vapor-suppressing foam to reduce fire risk .
4. Prevent the product from entering drains, water courses, or soil; dispose of collected material as hazardous waste according to local, state, and federal environmental regulations, as the compound may have aquatic toxicity .

1. Glyceryl monooleate CAS 111-03-5 is not classified as highly flammable in its pure form; however, industrial solutions in organic solvents such as hexane are highly flammable (Category 2) with flash points as low as -26°C, and may form explosive mixtures with air .
2. For fires involving the product, use dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray; do NOT use a direct water jet as it may scatter burning material and spread the fire .
3. Firefighters Glyceryl Monooleate should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Glyceryl monooleate due to hazardous decomposition gases generated by thermal decomposition, including carbon monoxide and carbon dioxide .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination .