Gamma-cyclodextrin CAS 17465-86-0

1. Gamma-cyclodextrin CAS 17465-86-0 is primarily used in the pharmaceutical and food industries as a complexing agent to enhance the solubility, stability, and bioavailability of poorly water-soluble active ingredients .
2. Gamma-cyclodextrin serves as an effective chiral selector in capillary electrophoresis and liquid chromatography for the enantiomeric separation of pharmaceutical compounds such as antihistamines and calcium channel blockers .
3. Gamma-cyclodextrin is employed as a formulation excipient in drug delivery systems, including in the marketed product Sugammadex (Bridion), a modified gamma-cyclodextrin used to reverse neuromuscular blockade .
4. Researchers utilize Gamma-cyclodextrin in supramolecular chemistry for building molecular inclusion complexes, and as a solubilizer for nutraceuticals such as cannabinoids and essential oils in cosmetic and beverage applications .

1. Gamma-cyclodextrin CAS 17465-86-0 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; the powder is stable for up to 3 years at -20°C or 2 years at 4°C .
2. Gamma-cyclodextrin is generally not classified as a hazardous substance under GHS criteria; however, it may cause mild skin, eye, and respiratory tract irritation .
3. Personnel should wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, avoiding formation of dust and aerosols .
4. Keep Gamma-cyclodextrin away from incompatible materials such as strong oxidizing agents; for solution storage, prepare aliquots in tightly sealed vials and use within 1 month at -20°C, avoiding repeated freeze-thaw cycles .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when Gamma-cyclodextrin is released .
2. Collect Gamma-cyclodextrin by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations; the substance is considered non-hazardous for transport.

1. Gamma-cyclodextrin CAS 17465-86-0 is not classified as highly flammable but may decompose under fire conditions, emitting irritant fumes .
2. Use Gamma-cyclodextrin water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Gamma-cyclodextrin due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .