Hesperetin CAS 520-33-2

1. Hesperetin CAS 520-33-2 is a naturally occurring citrus flavonoid primarily used in biomedical research for its antioxidant, anti-inflammatory, anticancer, and neuroprotective properties, with studies investigating its potential in conditions such as cardiovascular disease, diabetes, and neurodegeneration .
2. Hesperetin has been shown to induce apoptosis and cell cycle arrest in various cancer cell lines, while also demonstrating the ability to suppress cell invasion and metastasis through modulation of the urokinase plasminogen activator (uPA) pathway .
3. Hesperetin is utilized as a chiral building block in organic synthesis and as an analytical standard for the quantification of citrus flavonoids in food and pharmaceutical products .
4. In research, hesperetin is used to study the activation of the ERK/Nrf2 signaling pathway, inhibition of reactive oxygen species (ROS) generation, and modulation of the expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .

1. Hesperetin CAS 520-33-2 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; powder is stable for up to 3 years at -20°C or 2 years at 4°C .
2. For solution storage, prepare aliquots in tightly sealed vials and store at -20°C for up to 1 month or at -80°C for up to 6 months, avoiding repeated freeze-thaw cycles .
3. Hesperetin  is classified with hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" .
4. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when Hesperetin CAS 520-33-2 is released .
2. Collect Hesperetin by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal.
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. Hesperetin CAS 520-33-2 is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product .
3. Firefighters Hesperetin should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Hesperetin due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, and contain fire runoff to prevent environmental contamination .