Tauroursodeoxycholic Acid CAS 14605-22-2

1. Tauroursodeoxycholic acid is a hydrophilic bile acid primarily used to prevent and treat cholesterol gallstones by reducing cholesterol absorption, lowering bile cholesterol saturation, and increasing bile acid content in the gallbladder bile .
2. Tauroursodeoxycholic acid CAS 14605-22-2 possesses anti-apoptotic properties by inhibiting the mitochondrial pathway of cell death, reducing ER stress, and stabilizing the unfolded protein response, making it a therapeutic candidate for neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's, and Parkinson's disease .
3. In combination with sodium phenylbutyrate, tauroursodeoxycholic acid is approved for the treatment of amyotrophic lateral sclerosis (ALS) in adults under the brand names Albrioza and Relyvrio .
4. Researchers utilize Tauroursodeoxycholic acid CAS 14605-22-2 as a detergent for solubilizing lipids and membrane-bound proteins in biochemical studies, and it has demonstrated antioxidant activity in model membrane systems by decreasing oxygen consumption during lipid oxidation .

1. Tauroursodeoxycholic acid powder must be stored in a tightly sealed container at room temperature (15-25°C) or at -20°C for long-term stability, protected from light and moisture; the sodium salt form is stable for up to 3 years when stored properly .
2. Tauroursodeoxycholic acid CAS 14605-22-2 has a WGK Germany 3 classification (high water hazard potential) and should not be released into the environment .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, avoiding formation of dust and aerosols .
4. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases to prevent decomposition; for solution storage, prepare aliquots in DMSO or ethanol and store at -20°C for up to 1 month .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when tauroursodeoxycholic acid is released .
2. Collect Tauroursodeoxycholic acid CAS 14605-22-2 by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol .
4. Prevent the product from entering drains, water courses, or the soil; dispose of collected material according to local, state, and federal environmental regulations .

1. Tauroursodeoxycholic acid is classified as a combustible solid (Storage Class 11) and may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as Tauroursodeoxycholic acid CAS 14605-22-2 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning tauroursodeoxycholic acid due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, and contain fire runoff to prevent environmental contamination .