Pravadoline CAS 92623-83-1

1. Pravadoline CAS 92623-83-1 is primarily used as a research tool and pharmacological reference compound, notably as the first identified aminoalkylindole cannabinoid receptor agonist, which led to the development of widely used research agents like WIN 55,212-2 .
2. Pravadoline functions as a cyclooxygenase (COX) inhibitor, inhibiting prostaglandin synthesis in mouse brain with an IC50 of 4.9 µM, and displays antinociceptive activity in various rodent pain models .
3. Pravadoline exhibits a dual mechanism of action, acting as both a COX inhibitor and a cannabinoid receptor agonist, with its analgesic effects appearing at doses ten times lower than its anti-inflammatory dose and not being blocked by opioid antagonists such as naloxone .
4. Researchers Pravadoline utilize this product to study cannabinoid receptor pharmacology, particularly CB1 and CB2 receptor interactions, and to investigate aminoalkylindole structure-activity relationships in isolated tissue preparations including guinea pig ileum and mouse vas deferens .

1. Pravadoline CAS 92623-83-1 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and heat, with recommended storage at -20°C for long-term stability up to 3 years or at 4°C for up to 2 years .
2. Pravadoline contains a pharmaceutically active ingredient and is classified with hazard statements including R28 (very toxic if swallowed), R38 (irritating to skin), R41 (risk of serious damage to eyes), and possible risks of impaired fertility and harm to unborn child (R62, R63) .
3. Personnel must wear chemical-resistant rubber gloves, NIOSH/MSHA-approved respirators, chemical safety goggles, and impervious protective clothing when handling pravadoline, avoiding inhalation of dust and contact with skin, eyes, and clothing .
4. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong alkalis, and for solution storage, prepare aliquots in tightly sealed vials and use within 1 month at -20°C or 6 months at -80°C .

1. Isolate the spill area, ensure adequate ventilation, and avoid dust formation when pravadoline is released, wearing full personal protective equipment including self-contained breathing apparatus, chemical-resistant gloves, safety goggles, and protective clothing .
2. Collect Pravadoline by sweeping or vacuuming without creating dust using spark-proof tools, or absorb solutions with finely-powdered liquid-binding material such as diatomite or universal binders, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure, decontaminate surfaces and equipment by scrubbing with alcohol, and prevent the product from entering drains or water courses .
4. Dispose of collected Pravadoline material in accordance with prevailing country, federal, state, and local regulations, as the substance is considered non-hazardous for transport but contains a potent active ingredient requiring proper waste management .

1. Pravadoline CAS 92623-83-1 is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides during thermal decomposition .
2. Use water spray, dry chemical powder, foam, or carbon dioxide to extinguish fires involving the product .
3. Firefighters Pravadoline should wear self-contained breathing apparatus and full protective clothing when handling burning pravadoline due to hazardous decomposition gases and to prevent contact with skin and eyes .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff from fire control or dilution water to prevent environmental contamination and pollution .