1-Methyl-3-pyrrolidinol CAS 13220-33-2

1. 1-Methyl-3-pyrrolidinol is primarily used as a chiral building block and synthetic intermediate in organic synthesis and pharmaceutical research .
2. 1-Methyl-3-pyrrolidinol CAS 13220-33-2 is employed in the synthesis of diaryl acylaminopyrimidines as adenosine A2A antagonists and in the preparation of (alkoxyamino)(pyridinylamino)pyrazinecarbonitriles as selective checkpoint kinase 1 (CHK1) inhibitors with oral antitumor activities .
3. 1-Methyl-3-pyrrolidinol serves as a reactant in the asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors and in the synthesis of pharmacologically active stereoisomers of N-substituted soft anticholinergics .
4. The (R)-enantiomer is used to prepare analogs of istaroxime, a potent inhibitor of Na+,K+-ATPase, making it valuable for cardiovascular research applications .

1. 1-Methyl-3-pyrrolidinol must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment away from heat, sparks, and open flames, with long-term storage recommended at -20°C .
2. 1-Methyl-3-pyrrolidinol CAS 13220-33-2 is a combustible liquid with a flash point of 70°C (158°F) and should be kept away from ignition sources, strong acids, and strong oxidizing agents to prevent hazardous reactions .
3. Personnel must wear chemical-resistant gloves, safety goggles, and protective clothing when handling this substance, as it causes skin and eye irritation (H315, H319) and may cause respiratory irritation (H335) .
4. Avoid inhalation of vapors, ensure adequate ventilation in work areas (preferably a chemical fume hood), wash thoroughly after handling, and have emergency eyewash facilities readily accessible .

1. Isolate the spill area, eliminate all ignition sources, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves and safety goggles when 1-Methyl-3-pyrrolidinol is released .
2. Absorb 1-Methyl-3-pyrrolidinol CAS 13220-33-2 with inert material such as vermiculite, sand, or earth using spark-proof tools, and place into suitable closed containers for disposal, cleaning up spills immediately .
3. Avoid runoff into storm sewers and ditches which lead to waterways, and provide adequate ventilation during cleanup to prevent vapor accumulation .
4. Dispose of collected material according to local, state, and federal environmental regulations, as the substance may have environmental hazards requiring proper waste management .

1. 1-Methyl-3-pyrrolidinol is a combustible liquid with a flash point of 70°C (158°F), and vapors may be heavier than air, spreading along the ground and collecting in low or confined areas where containers may explode when heated .
2. Use dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray to extinguish fires involving the product, and use water spray to keep fire-exposed containers cool .
3. Firefighters should 1-Methyl-3-pyrrolidinol CAS 13220-33-2 wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved (or equivalent), and full protective gear when handling burning 1-Methyl-3-pyrrolidinol due to hazardous decomposition gases .
4. Hazardous decomposition products formed under fire conditions include carbon monoxide, carbon dioxide, and oxides of nitrogen, which are irritating and highly toxic gases generated by thermal decomposition or combustion .