Pimobendan CAS 74150-27-9

1. Pimobendan CAS 74150-27-9 is primarily used as a veterinary medication (brand name Vetmedin) for the management of congestive heart failure in dogs due to dilated cardiomyopathy (DCM) or valvular insufficiency .
2. Pimobendan functions as a selective inhibitor of phosphodiesterase III (PDE3) with an IC50 of 0.32 µM, while also exhibiting calcium-sensitizing properties that enhance myocardial contractility without increasing oxygen demand .
3. Pimobendan is employed in cardiovascular research as an inodilator, providing both positive inotropic effects through calcium sensitization of cardiac myofibrils and vasodilatory effects through PDE3 inhibition .
4. Researchers utilize Pimobendan in experimental models of heart failure, where studies have demonstrated that pimobendan treatment in EMC virus-induced myocarditis murine models significantly improved final survival rates from 33.6% (control) to 53.3% (0.1 mg/kg) or 66.7% (1 mg/kg) .

1. Pimobendan CAS 74150-27-9 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment at -20°C for long-term stability (up to 3 years in powder form), or at 2-8°C for shorter periods .
2. Pimobendan contains a pharmaceutically active ingredient requiring handling only by trained personnel, as it is classified with hazard statements including R28 (very toxic if swallowed), R38 (irritating to skin), and R41 (risk of serious damage to eyes) .
3. Personnel must wear chemical-resistant rubber gloves, NIOSH/MSHA-approved respirators, chemical safety goggles, and impervious protective clothing when handling pimobendan, avoiding inhalation of dust and contact with skin, eyes, and clothing .
4. Do not store aqueous solutions for more than one day, and keep the product away from incompatible materials such as strong acids/alkalis, strong oxidizing/reducing agents, and protect from light and heat .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including self-contained breathing apparatus and protective clothing when pimobendan CAS 74150-27-9 is released, avoiding dust formation .
2. Collect Pimobendan by sweeping or vacuuming without creating dust, or absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders), and place into suitable closed containers for disposal .
3. Decontaminate surfaces and equipment by scrubbing with alcohol, and prevent the product from entering drains or water courses due to potential environmental hazards .
4. Dispose of collected material in accordance with prevailing country, federal, state, and local regulations, as the substance is considered non-hazardous for transport but contains a potent active ingredient .

1. Pimobendan CAS 74150-27-9 is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides during thermal decomposition .
2. Use Pimobendan water spray, dry chemical powder, foam, or carbon dioxide to extinguish fires involving the product .
3. Firefighters should wear self-contained breathing apparatus and full protective clothing when handling burning pimobendan due to hazardous decomposition gases and to prevent contact with skin and eyes .
4. During combustion, may emit irritant fumes; contain fire runoff to prevent environmental contamination, and move containers from the fire area if safe to do so .