6-Bromo-2-naphthoic Acid CAS 5773-80-8

1. 6-Bromo-2-naphthoic acid is primarily used as a key pharmaceutical intermediate, most notably in the synthesis of Adapalene, a third-generation retinoid drug for topical acne treatment .
2. 6-Bromo-2-naphthoic acid CAS 5773-80-8 serves as a versatile building block in organic reactions such as Suzuki coupling and cyclizations, enabling the preparation of diverse naphthalene derivatives, fine chemicals, and benzimidazole derivatives .
3. 6-Bromo-2-naphthoic acid is employed as a precursor in the development of specialty dyes, agrochemicals, and organic electronic materials, leveraging its bromo and carboxylic acid functional groups for selective modification .
4. Researchers utilize 6-Bromo-2-naphthoic acid CAS 5773-80-8 in medicinal chemistry for synthesizing potential anti-cancer agents and in studies involving retinoic acid receptor (RAR) binding mechanisms, particularly with RARβ and RARγ subtypes .

1. 6-Bromo-2-naphthoic acid must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture, and kept away from strong oxidizing agents .
2. 6-Bromo-2-naphthoic acid CAS 5773-80-8 is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), requiring careful handling protocols .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling 6-Bromo-2-naphthoic acid, ensuring adequate ventilation in work areas .
4. Avoid formation of dust and aerosols, wash thoroughly after handling, and follow precautionary statements P261 (avoid breathing dust), P280 (wear protective gloves/eye protection), and P305+P351+P338 (IF IN EYES: rinse cautiously with water) .

1. Isolate the spill area, ensure adequate ventilation, and avoid dust formation when 6-Bromo-2-naphthoic acid is released, wearing full personal protective equipment including chemical-resistant gloves and safety goggles .
2. Collect 6-Bromo-2-naphthoic acid CAS 5773-80-8 by sweeping or vacuuming without creating dust, using non-sparking tools and explosion-proof equipment, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure, and prevent the product from entering drains or water courses due to potential environmental hazards .
4. Dispose of collected material according to local, state, and federal environmental regulations, preferably through licensed chemical destruction or controlled incineration with flue gas scrubbing .

1. 6-Bromo-2-naphthoic acid is not classified as highly flammable (NFPA fire rating of 0) but may decompose under fire conditions, with a flash point of approximately 125-188°C and boiling point of 387.3°C, emitting toxic fumes when involved in a fire .
2. Use dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray to extinguish fires involving the product, avoiding straight water streams that may spread burning material .
3. Firefighters 6-Bromo-2-naphthoic acid CAS 5773-80-8 should wear self-contained breathing apparatus and full protective gear when handling burning 6-Bromo-2-naphthoic acid due to hazardous decomposition gases including carbon monoxide, carbon dioxide, and hydrogen bromide .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray, and contain fire runoff to prevent environmental contamination .