Pyrroloquinoline Quinone Disodium Salt CAS 122628-50-6

1. Pyrroloquinoline quinone disodium salt is primarily used as a potent, redox-active compound in biomedical research, exhibiting antioxidant, neuroprotective, and mitochondrial biogenesis-enhancing properties with potential therapeutic roles in neurodegenerative diseases such as Alzheimer's and Parkinson's .
2. Pyrroloquinoline quinone disodium salt CAS 122628-50-6 functions as a dietary supplement ingredient (e.g., BioPQQ®) and novel food approved by FDA, EFSA, and Japanese authorities, supporting cognitive function, improving memory and attention in clinical trials, and reducing blood lipid peroxide levels in humans .
3. Pyrroloquinoline quinone disodium salt is employed in cosmeceutical research for its ability to suppress UVB-induced caspase-1 release in skin cells and reduce moisture loss, while also being investigated for anti-obesity effects through reducing visceral fat accumulation, suppressing lipogenesis, and improving mitochondrial function .
4. Researchers utilize Pyrroloquinoline quinone disodium salt CAS 122628-50-6 to study Nrf2/ARE antioxidant pathway activation, AMPK/PGC-1α-mediated mitochondrial biogenesis, and anti-inflammatory mechanisms via NF-κB inhibition, as well as to investigate its benefits in cerebral folate deficiency and metabolic disorders .

1. Pyrroloquinoline quinone disodium salt must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment at 2-8°C, protected from light and moisture to prevent degradation .
2. The product exhibits photosensitivity in aqueous solutions, with studies showing up to 92.29% degradation after 4 weeks of light exposure in liquid formulations; Pyrroloquinoline quinone disodium salt CAS 122628-50-6 has good stability in solid form under pressure and retains stability under various sterilization conditions (90°C/30 min, 121°C/15 min, 130°C/15 s) .
3. Personnel must wear chemical-resistant nitrile gloves, safety goggles with side-shields, and protective clothing when handling pyrroloquinoline quinone disodium salt, as it may cause skin and eye irritation, and should use dust respirators during bulk handling to prevent inhalation .
4. The compound is water-soluble (6.16 mg/mL, requires ultrasonic and warming), and solutions should be prepared in tightly sealed vials, used promptly, and protected from light; avoid incompatible materials such as strong oxidizing agents .

1. Isolate the spill area, ensure adequate ventilation, and avoid dust formation when pyrroloquinoline quinone disodium salt is released, wearing full personal protective equipment including nitrile gloves, safety goggles, and dust respirator .
2. Collect Pyrroloquinoline quinone disodium salt CAS 122628-50-6 by sweeping or vacuuming without creating dust, using non-sparking tools, and place into suitable closed containers for disposal, cleaning up spills immediately .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure, and prevent the product from entering drains or water courses due to potential environmental hazards .
4. Dispose of collected material according to local, state, and federal environmental regulations, as the substance requires proper waste management and should not be released into the environment .

1. Pyrroloquinoline quinone disodium salt is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides .
2. Use Pyrroloquinoline quinone disodium salt CAS 122628-50-6 dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray to extinguish fires involving the product, selecting appropriate extinguishing media based on surrounding environment .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning pyrroloquinoline quinone disodium salt due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray, contain fire runoff to prevent environmental contamination, and collect contaminated fire extinguishing water separately .