1-Fluoro-2-nitrobenzene CAS 1493-27-2

1. 1-Fluoro-2-nitrobenzene is a highly versatile intermediate in organic synthesis, serving as a critical building block for pharmaceuticals, pesticides, and dyes . Its structure, featuring an electron-withdrawing nitro group ortho to a fluorine atom, makes it an ideal substrate for nucleophilic aromatic substitution (SNAr) reactions .
2. 1-Fluoro-2-nitrobenzene CAS 1493-27-2 is widely used to synthesize substituted aromatic compounds by displacing the activated fluorine atom with nucleophiles like amines, alkoxides, and thiols, producing valuable derivatives such as 2-nitroaniline and 2-nitroanisole .
3. Applications of 1-Fluoro-2-nitrobenzene also include its role in biochemical research, where it has been studied for its antibacterial activity against *Staphylococcus aureus* and its cytotoxic effects on cancer cell lines, in addition to its use as an inhibitor of cytochrome P450 enzymes .

1. Store 1-Fluoro-2-nitrobenzene in a tightly sealed container in a cool, dry, and well-ventilated place. Recommended storage temperatures are between 2-8°C (refrigerated) to maintain stability . Protect from light and avoid prolonged exposure to air .
2. Keep 1-Fluoro-2-nitrobenzene away from strong oxidizing agents and strong bases, as these materials are incompatible .
3. Always use 1-Fluoro-2-nitrobenzene CAS 1493-27-2 appropriate personal protective equipment (PPE) including chemical-resistant gloves (butyl-rubber recommended), face shield, and safety glasses. Handle only with adequate ventilation in a fume hood and avoid breathing vapors, mist, or dust .

1. Immediately isolate the spill area, ensure adequate ventilation, and evacuate personnel to safe areas. Contain 1-Fluoro-2-nitrobenzene using inert, non-combustible absorbent material and absolutely prevent it from entering drains or waterways .
2. Carefully collect 1-Fluoro-2-nitrobenzene CAS 1493-27-2 and place it into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear suitable PPE including self-contained breathing apparatus during cleanup. 1-Fluoro-2-nitrobenzene is classified for transport (UN2810 or UN2811, Hazard Class 6.1, PG III) .

1. 1-Fluoro-2-nitrobenzene is classified as a highly toxic substance (GHS06, GHS08, GHS09, Danger) with hazard statements including H301 (Toxic if swallowed, LD50 oral rat 320 mg/kg), H311 (Toxic in contact with skin, LD50 dermal rat 535 mg/kg), and H331 (Toxic if inhaled, LC50 inhalation rat 2.26 mg/L/4h) . 1-Fluoro-2-nitrobenzene CAS 1493-27-2 may also cause damage to organs through prolonged or repeated exposure (H373) .
2. 1-Fluoro-2-nitrobenzene has a flash point of 94°C and a boiling point of 116°C at 22 mmHg . Thermal decomposition or combustion produces toxic and corrosive fumes including hydrogen fluoride, carbon oxides, and nitrogen oxides . It is very toxic to aquatic life with long-lasting effects (H411) .
3. Always consult 1-Fluoro-2-nitrobenzene CAS 1493-27-2 the specific Safety Data Sheet (SDS) for 1-Fluoro-2-nitrobenzene for complete hazard information, first-aid procedures (P301+P310 for ingestion, P302+P352+P312 for skin, P304+P340+P312 for inhalation), and handling instructions; precautionary statements include P260 (do not breathe vapors), P273 (avoid release to environment), P280 (wear protective gloves/eye protection), and P403+P233 (store in well-ventilated place, keep container tightly closed) .