3-Iodophenol CAS 626-02-8

1. 3-Iodophenol is a versatile building block used in various organic reactions including esterification, electrophilic aromatic substitution, alkylation, Mitsunobu reaction, and transition metal-catalyzed cross-coupling reactions . 3-Iodophenol CAS 626-02-8 is employed in the synthesis of centrally acting H2 receptor histamine antagonists and various cell-permeable probes for biological assays .
2. The compound serves as a precursor for synthesizing iodinated coumarins investigated as potential anti-cancer and anti-mycobacterial agents, and participates in palladium-catalyzed cross-coupling reactions in aqueous media . 3-Iodophenol CAS 626-02-8 is also used in glucuronidation studies involving the UGT1A6 enzyme .

1. Store 3-Iodophenol in a tightly sealed container in a cool, dry, well-ventilated place, protected from light as it is light-sensitive . Recommended storage temperatures include refrigeration (2-8°C), a cool dark place (<15°C), or long-term storage at -20°C .
2. Keep 3-Iodophenol away from strong oxidizing agents to prevent hazardous reactions .
3. Always use appropriate personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, and protective clothing when handling 3-Iodophenol CAS 626-02-8 to avoid skin, eye, and respiratory contact .

1. Immediately isolate the spill area, avoid dust formation, and contain 3-Iodophenol using inert, non-combustible absorbent material; prevent material from entering drains or waterways .
2. Carefully sweep up the spilled solid using clean, non-sparking tools and place 3-Iodophenol CAS 626-02-8 into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear suitable PPE during cleanup; under fire conditions, thermal decomposition produces toxic and irritating fumes including carbon monoxide, carbon dioxide, and hydrogen iodide, requiring self-contained breathing apparatus .

1. 3-Iodophenol is classified as an irritant (GHS signal word "Warning"), causing skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335) . 3-Iodophenol CAS 626-02-8 is harmful if swallowed (H302) with a mouse oral LD50 of 2900 mg/kg .
2. 3-Iodophenol has a flash point >110°C (230°F) and is combustible . It is slightly soluble in water, soluble in DMSO, chloroform, and ethyl acetate, with a melting point of 38-44°C . 3-Iodophenol CAS 626-02-8 may be harmful to aquatic life .
3. Always consult the specific Safety Data Sheet (SDS) for 3-Iodophenol for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P302+P352 for skin), and handling instructions; precautionary statements include P261 (avoid breathing dust), P264 (wash skin thoroughly after handling), and P280 (wear protective gloves/eye protection) .