3-Methoxyphenylacetic Acid CAS 1798-09-0

1. 3-Methoxyphenylacetic acid is primarily used as a key intermediate in the pharmaceutical industry for the synthesis of various active pharmaceutical ingredients (APIs), particularly those related to pain management and anti-inflammatory treatments . It also serves as a building block in the synthesis of pesticides, dyes, and other fine chemicals .
2. 3-Methoxyphenylacetic acid CAS 1798-09-0 is also a naturally occurring phytotoxin produced by the fungus *Rhizoctonia solani* AG-3 TB, the causal agent of tobacco target spot disease, where it can cause necrosis in tobacco leaves .
3. Applications of 3-Methoxyphenylacetic acid extend to its use as a versatile research chemical in medicinal chemistry and synthetic organic chemistry for creating more complex molecular structures .

1. Store 3-Methoxyphenylacetic acid in a tightly sealed container in a cool, dry, and well-ventilated area. Recommended storage conditions are below +30°C or in a cool place away from incompatible substances .
2. Keep 3-Methoxyphenylacetic acid away from strong oxidizing agents to prevent hazardous reactions . It is stable under normal temperatures and pressures .
3. Always 3-Methoxyphenylacetic acid CAS 1798-09-0 use appropriate personal protective equipment (PPE) including chemical-resistant gloves (nitrile rubber recommended), safety goggles, and protective clothing when handling 3-Methoxyphenylacetic acid to avoid skin, eye, and respiratory contact. Avoid generating dust and ensure adequate ventilation .

1. Immediately isolate the spill area, avoid dust formation, and contain 3-Methoxyphenylacetic acid using inert, non-combustible absorbent material. Prevent material from entering drains or waterways .
2. Carefully sweep up or shovel the spilled solid using clean tools and place 3-Methoxyphenylacetic acid CAS 1798-09-0 into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear suitable PPE during cleanup; under fire conditions, thermal decomposition produces toxic and irritating fumes including carbon oxides, requiring self-contained breathing apparatus .

1. 3-Methoxyphenylacetic acid is classified as an irritant (GHS signal word "Warning"), causing skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335) . 3-Methoxyphenylacetic acid CAS 1798-09-0 has an NFPA health rating of 2 .
2. 3-Methoxyphenylacetic acid is combustible with a flash point of approximately 124°C . Its melting point range is 65-73°C . An acute toxicity study reports an intravenous LD50 of 180 mg/kg in mice . 3-Methoxyphenylacetic acid CAS 1798-09-0 is slightly soluble in water .
3. Always consult the specific Safety Data Sheet (SDS) for 3-Methoxyphenylacetic acid for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P302+P352 for skin), and handling instructions. Precautionary statements include P261 (avoid breathing dust), P264 (wash skin thoroughly after handling), and P280 (wear protective gloves/eye protection) .