Triethyl Orthoformate / TEOF CAS 122-51-0

1. Triethyl orthoformate is a versatile reagent in organic synthesis for preparing esters, heterocycles, and other derivatives, making it valuable in pharmaceutical and agrochemical industries .
2. TEOF CAS 122-51-0 serves as a key intermediate in the synthesis of antimalarial drugs (chloroquine), the miticide bisamisamide, and the herbicide pyrazosulfuron .
3. Triethyl orthoformate is commonly used as a protecting group for alcohols and amines, as a solvent in chemical reactions, and in the synthesis of high-purity methine and cyanine dyes for photographic materials .

1. Store Triethyl orthoformate in a tightly sealed container in a cool, dry, well-ventilated place below 30°C, as Triethyl orthoformate is moisture sensitive and decomposes in contact with water .
2. Keep TEOF CAS 122-51-0 strictly away from heat, sparks, open flames, strong oxidizing agents, and acids to prevent fire or explosion hazards .
3. Handle Triethyl orthoformate using appropriate personal protective equipment including chemical-resistant gloves (butyl-rubber) and safety goggles, and use in a fume hood with explosion-proof equipment to avoid breathing vapors .

1. Isolate the TEOF CAS 122-51-0 spill area immediately, eliminate all ignition sources, and wear full protective equipment including self-contained breathing apparatus before handling Triethyl orthoformate .
2. Contain liquid Triethyl orthoformate using dry inert non-combustible absorbent material like sand, collect using non-sparking tools into sealed, labeled containers for disposal, and prevent entry into drains or waterways .
3. Personnel cleaning Triethyl orthoformate spills must not use water jet on the spill and should dispose of waste through a licensed chemical destruction facility, as Triethyl orthoformate is classified for transport (UN2524, Hazard Class 3, PG III) .

1. Triethyl orthoformate is classified with GHS signal word "Warning" as a flammable liquid and vapor (H226, flash point 27-35°C) that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335) .
2. TEOF CAS 122-51-0 has low acute toxicity with oral LD50 of 7060 mg/kg in rats and dermal LD50 >10 mL/kg in guinea pigs, but vapors are heavier than air and may form explosive mixtures (0.7-25.1% in air) .
3. Triethyl orthoformate is stable under recommended conditions but decomposes in contact with acids and water; thermal decomposition produces toxic fumes including carbon monoxide and carbon dioxide, and NFPA health, flammability, and reactivity ratings are 0, 3, and 0 respectively .