1-(Oxetan-3-yl)piperazine CAS 1254115-23-5

1. 1-(Oxetan-3-yl)piperazine CAS 1254115-23-5 is primarily used as a key intermediate for synthesizing pharmaceuticals, including potential central nervous system (CNS) drugs and antiviral agents, leveraging its unique piperazine-oxetane scaffold to enhance bioactivity .
2. 1-(Oxetan-3-yl)piperazine serves as a versatile building block in organic synthesis for preparing piperazine-oxetane derivatives, heterocyclic compounds, and biologically active molecules for research and development .
3. 1-(Oxetan-3-yl)piperazine is employed as a precursor for specialty ligands, agrochemical intermediates, and fine chemical intermediates, where its amino groups enable versatile coupling and functionalization reactions .
4. Patent literature indicates 1-(Oxetan-3-yl)piperazine is utilized in developing pharmaceutical candidates such as Mcl1 inhibitors, Mer tyrosine kinase inhibitors, and FGFR4 inhibitors, highlighting its importance in drug discovery research .

1. 1-(Oxetan-3-yl)piperazine CAS 1254115-23-5 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment at 2-8°C, protected from light and moisture, with long-term storage under inert atmosphere (argon) recommended .
2. The product is classified with GHS hazard statements H302+H312+H332 (Harmful if swallowed, in contact with skin or if inhaled), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation) .
3. Personnel 1-(Oxetan-3-yl)piperazine must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .
4. Keep away from heat, sparks, open flames, and incompatible materials such as strong oxidizing agents, strong acids, and strong bases to prevent decomposition or ring-opening reactions .

1. Isolate the spill area, ensure adequate ventilation, remove all sources of ignition, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and appropriate respiratory protection when 1-(Oxetan-3-yl)piperazine CAS 1254115-23-5 is released .
2. Collect 1-(Oxetan-3-yl)piperazine using spark-proof tools by sweeping or vacuuming without creating dust, or absorb with inert materials (diatomite, universal binders), and place into suitable closed containers for disposal .
3. Avoid creating dust or vapor clouds during cleanup to prevent respiratory exposure, decontaminate surfaces using appropriate methods, and prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration with flue gas scrubbing .

1. 1-(Oxetan-3-yl)piperazine CAS 1254115-23-5 has a boiling point of approximately 227.2±25.0°C and may emit toxic fumes including carbon oxides and nitrogen oxides under fire conditions; the product is not classified as highly flammable but should be treated as combustible .
2. Use dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product, selecting appropriate extinguishing media based on surrounding environment .
3. Firefighters 1-(Oxetan-3-yl)piperazine should wear self-contained breathing apparatus and full protective gear when handling burning 1-(Oxetan-3-yl)piperazine due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray, and contain fire runoff to prevent environmental contamination and pollution .