Tetrahydro-4-pyranol CAS 2081-44-9

1. Tetrahydro-4-pyranol CAS 2081-44-9 is primarily used as a versatile intermediate in organic synthesis for the development of pharmaceuticals, agrochemicals, and specialty chemicals due to its bifunctional structure featuring both ether and alcohol groups .
2. Tetrahydro-4-pyranol serves as a valuable building block in carbohydrate chemistry and fine chemical manufacturing, where controlled reactivity and functional group compatibility are essential for constructing complex molecular architectures .
3. Tetrahydro-4-pyranol is employed as a reagent in high-temperature liquid water reactions with high-pressure carbon dioxide for enhancing cyclic ether formation from polyalcohol compounds .
4. Researchers utilize Tetrahydro-4-pyranol as a key intermediate in medicinal chemistry for synthesizing therapeutic agents, particularly in applications requiring the stability and solubility provided by its saturated six-membered heterocyclic ring system .

1. Tetrahydro-4-pyranol CAS 2081-44-9 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from heat and open flames, with recommended storage at -20°C for long-term stability .
2. Tetrahydro-4-pyranol is classified as a combustible liquid with a flash point of 88°C, requiring storage away from ignition sources, strong oxidizing agents, acid chlorides, and acid anhydrides to prevent hazardous reactions .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, face protection, and protective clothing when handling tetrahydro-4-pyranol, as Tetrahydro-4-pyranol causes serious eye damage (H318) and is classified with GHS signal word "Danger" .
4. Avoid inhalation of vapors or mist, ensure adequate ventilation in work areas (preferably a chemical fume hood), wash thoroughly after handling, and follow precautionary statements P280 (wear protective gloves/eye protection) and P305+P351+P338 (IF IN EYES: rinse cautiously with water) .

1. Isolate the spill area, ensure adequate ventilation, remove all sources of ignition, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and appropriate respiratory protection when tetrahydro-4-pyranol CAS 2081-44-9 is released .
2. Contain and collect Tetrahydro-4-pyranol using an electrically protected vacuum cleaner or by wet-brushing, or cover with dry lime or soda ash, using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating vapors or mists during cleanup, beware of vapors accumulating to form explosive concentrations in low areas, and prevent the product from entering drains or water courses due to potential environmental hazards .
4. Dispose of collected material according to local, state, and federal environmental regulations, preferably through licensed chemical destruction or controlled incineration in a chemical incinerator equipped with afterburner and scrubber .

1. Tetrahydro-4-pyranol CAS 2081-44-9 is a combustible liquid with a flash point of 88°C (190°F) and NFPA fire rating of 1, requiring considerable preheating before ignition, but may emit toxic fumes including carbon oxides under fire conditions .
2. Use alcohol-resistant foam, dry chemical powder, carbon dioxide, or water spray to extinguish fires involving the product, avoiding straight water streams that may spread the fire .
3. Firefighters Tetrahydro-4-pyranol should wear self-contained breathing apparatus and full protective gear when handling burning tetrahydro-4-pyranol due to hazardous decomposition gases including carbon monoxide and carbon dioxide generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray, and contain fire runoff to prevent environmental contamination .