2-Tetrahydrofuroic Acid CAS 16874-33-2

1. 2-Tetrahydrofuroic acid is widely utilized as a key intermediate in pharmaceutical synthesis, notably for the production of the antibiotic furopenem, the super influenza drug Xofluza, and the alpha-1 blocker alfuzosin used to treat benign prostatic hyperplasia .
2. The chiral forms of 2-Tetrahydrofuroic acid CAS 16874-33-2, (R)- and (S)-2-tetrahydrofuroic acid, serve as important ligand synthons in asymmetric synthesis reactions and as intermediates for preparing cephalosporin antibiotics, hormone-releasing hormones (LHRH), and VLA-4 antagonists .
3. In polymer chemistry, 2-Tetrahydrofuroic acid CAS 16874-33-2 is used in the production of biodegradable polymers, contributing to environmentally friendly materials . It is also employed as a standard in analytical chemistry to improve the accuracy of chemical analysis .
4. Researchers utilize this compound as a versatile reagent in organic synthesis and in the formulation of agrochemicals, including effective pesticides and herbicides . A patent describes its use in a method for protease resolution to prepare chiral (R)- and (S)-2-tetrahydrofuroic acid .

1. 2-Tetrahydrofuroic acid must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, with recommended storage at 2-8°C or below +30°C, protected from light and moisture . Containers opened must be carefully resealed and kept upright .
2. 2-Tetrahydrofuroic acid CAS 16874-33-2 is classified as a corrosive substance with GHS hazard statements H302 (Harmful if swallowed), H314 (Causes severe skin burns and eye damage), and H318 (Causes serious eye damage) . It has a WGK Germany rating of 3, indicating high water hazard potential .
3. Personnel must wear chemical-resistant gloves, tightly fitting safety goggles, face protection (8-inch minimum), and complete chemical protective suit when handling this substance . Use only in a chemical fume hood and avoid breathing vapors, mists, or dust .
4. Keep away from incompatible materials such as strong oxidizing agents . The material is extremely destructive to tissue of the mucous membranes, upper respiratory tract, eyes, and skin .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including self-contained breathing apparatus when 2-tetrahydrofuroic acid is released .
2. Collect 2-Tetrahydrofuroic acid CAS 16874-33-2 by soaking up with non-combustible, inert absorbent materials such as sand, earth, diatomaceous earth, or vermiculite using non-sparking tools, and place into suitable closed containers for disposal . Do NOT get water inside containers .
3. Avoid creating vapors or mists during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses as discharge into the environment must be avoided .
4. Dispose of collected 2-Tetrahydrofuroic acid CAS 16874-33-2 material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. 2-Tetrahydrofuroic acid is combustible with a flash point ranging from 110-139°C (closed cup) and NFPA fire rating of 0 (materials that will not burn) to 1 depending on the source; under fire conditions, hazardous decomposition products include toxic fumes of carbon monoxide and carbon dioxide .
2. Use water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide to extinguish fires involving the product; do NOT use a direct water jet as 2-Tetrahydrofuroic acid CAS 16874-33-2 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 2-tetrahydrofuroic acid due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant, corrosive, and/or toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination and pollution .